Inflammation-induced activation of the tryptophan catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) causes depressive-like behavior in mice following acute activation of the …

Here we investigated the mechanism of IDO expression induced by LPS in primary cultures of microglia derived from neonatal C57BL/6J mice. LPS (10 ng/ml) induced IDO transcripts that …

2010年8月2日 · Transient stimulation of the innate immune system by an intraperitoneal injection of lipopolysaccharide (LPS) activates peripheral and central expression of the tryptophan …

采用IDO1活性上调引起的Trp浓度降低、Kyn浓度升高及Kyn/Trp比值增大，来评价IDO1抑制剂L-1-MT和TQ016对急性炎症小鼠血清中上调的IDO1活性的抑制效果。</sec> <sec>结果尾静脉注 …

2018年10月29日 · To elucidate the biological role of Ido2 in immune function, we introduced lipopolysaccharide (LPS) endotoxin shock to Ido2 knockout (Ido2 KO) mice, which led to …

We report that peripheral administration of lipopolysaccharide (LPS) activates IDO and culminates in a distinct depressive-like behavioral syndrome, measured by increased duration of …

2009年11月13日 · In this study, we demonstrated that lipopolysaccharide (LPS) markedly increased nitric oxide (NO) production and indoleamine 2,3-dioxygenase (IDO) activity in …

2018年10月29日 · Indoleamine 2,3-dioxygenase 2 (Ido2) is a recently identified catalytic enzyme in the tryptophan-kynurenine pathway that is expressed primarily in monocytes and dendritic …

2010年2月1日 · LPS (10 ng/ml) induced IDO transcripts that peaked at 8 h and enzymatic activity at 24 h, resulting in an increase in extracellular kynurenine, the catabolic product of IDO …

通过动物模型实验显示:在中枢或外周给予脂多糖 (Lippolysaccharide，LPS)、IFN-α等促炎性细胞因子会导致小鼠体内IDO的表达增强，导致抑郁样行为的发生;反之，若提前给予IDO竞争性抑 …