Oncostatin M expression induced by bacterial triggers drives …
2022年1月12日 · We show here that bacterial lipopolysaccharide (LPS) induces oncostatin M (OSM) and that airway biopsies from patients with severe asthma present with an OSM-driven …
Science子刊：揭示细菌脂多糖诱导抑瘤素M表达从而触发重症哮喘 …
2022年4月20日 · 我们在这项新的研究中发现，细菌LPS诱导OSM表达，重症哮喘患者的气道活组织呈现出OSM驱动的转录特征。 Headland补充说，“这种情况与炎症途径和粘液生成途径的激 …
Anti-oncostatin M antibody puts brakes on asthma exacerbations
2022年2月2日 · An anti-OSM antibody reduces acute exacerbations in a mouse model. Bacteria contain lipopolysaccharide (LPS), which binds to Toll-like receptor 4 (TLR4) and activates …
Science子刊里程碑：哮喘治疗新靶点——OSM - 网易
2022年1月15日 · 为了明确细菌触发哮喘的相关机制，研究人员从细菌的主要分泌物脂多糖（lps）入手寻找答案。 LPS所诱导分泌的促炎分子主要有IL-α、IL-β、TNF-α、IL-8等等，除 …
IL-27 promotes nitric oxide production induced by LPS
2013年4月1日 · IL-27 together with lipopolysaccharide (LPS) induced morphological change into more spread and elongated cells and synergistically enhanced NO production. The combined …
Oncostatin M and TLR-4 Ligand Synergize to Induce MCP-1, IL-6, …
Our findings that LPS and OSM synergized to enhance VEGF levels in the supernatants of HAoAFs and HAoSMCs suggest another mechanism by which OSM or LPS could impact …
Oncostatin M Production and Regulation by Human …
1999年2月15日 · Oncostatin M (OSM) is an interleukin-6 (IL-6) family cytokine known in particular to induce the synthesis of acute-phase proteins by hepatocytes. Because human …
2022年1月12日 · We show here that bacterial lipopolysaccharide (LPS) induces oncostatin M (OSM) and that airway biopsies from patients with severe asthma present with an OSM-driven …
Oncostatin M and TLR-4 Ligand Synergize to ... - Wiley Online …
ELISAs performed on cell supernatants showed that stimulation with OSM alone caused increased MCP-1, IL-6, and VEGF levels. When combined, LPS and OSM synergized to …
抑瘤素M联合脂多糖诱导的人鼻粘膜上皮细胞炎症模型、制法以及 …
2021年6月29日 · 7.针对现有技术中存在的技术问题，本发明提供了一种抑瘤素m (osm)联合脂多糖 (lps)诱导人鼻粘膜上皮细胞炎症模型、制法以及应用，其是先使用osm刺激鼻腔黏膜上皮细 …
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