CDD | 唐靖/刘志峰团队合作揭示EGFR激酶活性和Rab GTPases协调EGFR …
表皮生长因子受体 （Epidermal Growth Factor Receptor, EGFR）是一种跨膜受体酪氨酸激酶，参与调节巨噬细胞 LPS /TLR4信号传导 [3]。 唐靖 课题组前期研究也发现，EGFR磷酸化协 …
EGFR tyrosine kinase activity and Rab GTPases coordinate EGFR
2022年11月7日 · Here, we show that LPS promotes high levels cell surface expression of EGFR in macrophages through two different transport mechanisms. On one hand, Rab10 is required …
CDD丨EGFR 和 Rab GTPases 协调 EGFR 运输以调节脓毒症中的巨 …
Here, we show that LPS promotes high levels cell surface expression of EGFR in macrophages through two different transport mechanisms. On one hand, Rab10 is required for …
Transactivation of EGFR by LPS Induces COX-2 Expression in …
Epidermal growth factor receptor (EGFR) activation prevents experimental NEC and may play a critical role in LPS-stimulated COX-2 production. We hypothesized that EGFR is required for …
EGFR tyrosine kinase activity and Rab GTPases coordinate EGFR ...
2022年11月7日 · Here, we show that LPS promotes high levels cell surface expression of EGFR in macrophages through two different transport mechanisms. On one hand, Rab10 is required …
Inhibition of epidermal growth factor receptor attenuates LPS …
In this study, we investigated the effects of EGFR inhibition on lipopolysaccharides (LPS)-induced ALI in rats. In addition, we evaluated the anti-inflammatory effects of EGFR inhibition or …
Erlotinib protects against LPS-induced endotoxicity because ... - PubMed
2015年8月4日 · In mice, erlotinib blocks the LPS-induced expression of tumor necrosis factor α (TNFα) and interleukin-6 (IL-6) and ameliorates LPS-induced endotoxity, revealing that EGFR …
Interrelation among TLR4, EGFR and Rab Proteins Induced by LPS
2020年7月20日 · TLR4, as an on-membrane receptor of LPS, plays a crucial part in the process of sepsis, and EGFR phosphorylation promotes cell inflammation in response to LPS, which …
TGF-α/EGFR signaling promotes lipopolysaccharide-induced …
2024年4月1日 · In the present study, we report that LPS induces EGFR activation through TLR4/TACE/TGF-α signaling, leading to LOX overactivation and Cdc42 inhibition, and disrupts …
Transactivation of EGFR by LPS Induces COX-2 Expression in
2012年5月31日 · Our data show that inhibiting EGFR kinase activity blocks LPS-induced COX-2 expression in small intestinal epithelial cells. LPS induction of COX-2 requires Src-family …