4 天之前 · The healthy gut is colonised by a commensal microbiota that releases large amounts of lipopolysaccharide (LPS), a potent immune stimulant, into the gut lumen (~80 µg LPS ml-1 in mouse caecum) 1 ...

Mice were injected intravenously with saline, LPS (5 μg/mouse), tumour necrosis factor-alpha (TNF-α) (10 ng/mouse) and IL-1β (20 or 100 ng/mouse). Blood samples were obtained 2 h post-treatment and plasma corticosterone concentration was determined by radioimmunoassay as detailed in Materials and Methods.

Preclinical in vivo models of lipopolysaccharide (LPS) -induced acute lung injury are commonly used to recapitulate pathophysiological features of chronic obstructive pulmonary disease and acute exacerbations. The LPS-induced lung inflammation is well described; however, whether the inflammatory res …

2021年5月17日 · Here, we investigated the responses of mouse primary microglia upon LPS and poly (I:C) stimulation by detecting various phenotypes ranging from morphology, proliferation, secretion, chemotaxis,...

2022年2月14日 · In this study, in LPS-stimulated mouse intestinal epithelial cells, METTL3 knockdown enhanced cell viability and suppressed cell apoptosis, as well as decreased the cleavage of pro-apoptotic ...

2022年9月5日 · This study established two depressive mouse models by maternal separation (MS) or lipopolysaccharide (LPS) administration, and added fluoxetine treatment group respectively for comparison. MS induced more apparent anxiety-like behavior while LPS induced more apparent depressive-like behavior.

In this study, we established an LPS-induced bone loss mouse (LPS mouse) model to research the number of osteoclasts and osteoblasts, and we observed osteoblast activity in vivo through calcein double-labeling experiment and the expression of osteogenic genes.

2012年10月1日 · Budesonide given per os prevented the LPS-induced lung inflammation and lung dysfunction. These results demonstrate a temporal relationship between the peak of inflammatory cell influx and significant impairment of lung function, suggestive of …

2012年9月4日 · 这里描述的是一种技术，其中脂多糖注入泌乳小鼠乳腺通过乳头模拟乳腺炎，通常由细菌感染引起的一个条件。 脂多糖（LPS）的结果中增加核因子kappa B（NF-κB）信号，通过NF-κB荧光素酶报告基因小鼠的生物发光成像的可视化。

In a mouse model of peripheral LPS-induced neuroinflammation, L-NBP treatment significantly suppressed the expression of pro-inflammatory cytokines, such as TNF-α, IL-1β and IL-6, as well as the activation of microglia in the brain [136].