Cell Reports丨CD14在细胞内LPS传感中的独立于TLR4的关键作用
CD14 是一种糖磷脂酰肌醇锚定的质膜蛋白，在 LPS 介导的 TLR4 激活中具有长期确定的作用；CD14 与 LPS 结合并将 LPS 转移到 TLR4-MD2 复合物，从而启动 myddosome 组装和信号 …
cd14 - 百度百科
CD14，即 LPS （Lipopolysaccharide）受体，最初是一种存在于 单核细胞 、 巨噬细胞 等 细胞表面 的 白细胞 分化抗原，由TODD于1981年首次从人单核细胞表面发现。
CD14—细菌脂多糖的膜受体 - 知乎 - 知乎专栏
cd14是革兰阴性菌内毒素脂多糖lps和lps结合蛋白复合物的高亲和力受体。cd14识别并结合lps，引起细胞酪氨酸磷酸化、核因子nf-κb转位、触发细胞因子释放和氧自由基产生，在机体免疫、 …
CD14: Biology and role in the pathogenesis of disease
2019年8月1日 · CD14 binds to Peptidoglycan (PGN) with partially identical conformational binding sites on CD14 compared with LPS and then leads to TLR2-mediated transcription factors NF …
Lipopolysaccharide (LPS)-binding protein stimulates CD14 ... - PubMed
2018年6月29日 · The secretory form of the CD14 (sCD14) induced internalization but required a much higher concentration than LBP. An inhibitory anti-sCD14 mAb was ineffective for serum …
Lipopolysaccharide (LPS)-binding protein stimulates CD14 …
LPS stimulation of CD14-expressing cells induced TLR4 internalization in the presence of serum, and an inhibitory anti-LBP mAb blocked its internalization. Addition of LBP to serum-free …
CD14 controls the LPS-induced endocytosis of Toll-like Receptor 4
Collectively, these data establish that the natural coexpression of CD14 and TLR4 determines which cell types internalize TLR4 in response to LPS. CD14 mediates the LPS-induced …
Multifaceted role of CD14 in innate immunity and tissue …
2023年12月1日 · CD14, a co-receptor for TLR4, recognizes LPS, PAMPs, and DAMPs in innate immunity. CD14 has a role in TLR4-dependent and TLR4-independent signaling pathways. …
A TLR4-independent critical role for CD14 in intracellular LPS …
2022年5月3日 · Our data show that LPS internalization via CD14 is a consequential event that enables cytosolic translocation of LPS, licensing pyroptotic and IL-1 responses from the host.
CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS ...
1990年9月21日 · CD14, a differentiation antigen of monocytes, was found to bind complexes of LPS and LBP, and blockade of CD14 with monoclonal antibodies prevented synthesis of TNF …