Lipopolysaccharide (LPS) and monophosphoryl lipid A (MPLA) induce, overall, similar transcriptional profiles in healthy individuals, although LPS has been shown to more potently induce pro-inflammatory cytokines. We explore herein whether MPLA could be considered as a synthetic replacement of LPS in …

2021年5月1日 · Principal component analysis of the 93-gene molecular response to MPLA and LPS stimulation found that the main variability was driven by stimulation in HV and by pathophysiology in SP. MPLA was a stronger inducer of the HLA family genes than LPS in both populations, arguing for divergent signalling pathways downstream of TLR-4.

2018年5月4日 · We deciphered the mechanisms of production of pro- and anti-inflammatory cytokines by adherent human blood mononuclear cells (PBMC) activated by lipopolysaccharide (LPS) or monophosphoryl lipid A...

2017年7月7日 · Monophosphoryl lipid A (MPLA) is a detoxified derivative of LPS that induces tolerance to LPS and augments host resistance to bacterial infections.

2017年4月4日 · MPLA is a detoxified form of LPS and has been proved by FDA for vaccines. To address whether PEG-PE micellization can influence MPLA adjuvant activity, RAW264.7 cells were stimulated with...

2007年6月15日 · Monophosphoryl lipid A (MPLA) is a low-toxicity derivative of LPS with useful immunostimulatory properties, which is nearing regulatory approval for use as a human vaccine adjuvant.

2024年11月15日 · 文 l WT 单磷酸脂质A（Monophosphoryl Lipid A，MPL/MPLA）是革兰氏阴性菌细胞壁中脂多糖（Lipopolysaccharide，LPS）中的最内层脂质A部分 [1]，虽被广泛用作疫苗、过敏药物和免疫治疗的佐剂，以增强免疫应答 [2] 是开发新型疫苗佐剂的重要靶分子，由沙门氏菌突变株 Salmonella ...

2017年1月5日 · Monophosphoryl lipid A (MPLA), a less toxic derivative of lipopolysaccharide (LPS), is employed as a vaccine adjuvant and is under investigation as a...

2017年7月1日 · Monophosphoryl lipid A (MPLA) is a detoxified derivative of LPS that induces tolerance to LPS and augments host resistance to bacterial infections. Previously, we demonstrated that LPS inhibits [Formula: see text] absorption in the medullary thick ascending limb (MTAL) through a basolateral Toll-lik …

2019年9月1日 · Pretreatment with the nontoxic immunomodulator monophosphoryl lipid A (MPLA) prevents inhibition by LPS through activation of a TLR4-TIR-domain-containing adaptor-inducing interferon-β (TRIF)-phosphatidylinositol 3-kinase (PI3K) pathway that …