2021年1月4日 · TAK1 activation requires TAK1-binding protein 1 (TAB1), TAB2, and TAB3. TAB1 is an adaptor protein constitutively associated with N-terminal kinase domain of TAK1 even in the unstimulated cells, while TAB2 and TAB3 bind to the C-terminus of TAK1 through TAK1-binding domain after stimulation (33 – 36).

2014年2月20日 · In the current study, we explore and identify TAB1 as a molecular and functionally distinct target of TP in macrophages by using a comprehensive approach that combines pull-down assays and in vitro assessments, such as molecular spectroscopy methods and isothermal titration microcalorimetry (ITC), as well as pharmaceutical and biological ...

2021年5月20日 · Knockout of Trim26 inhibited TAK1 activation and downstream kinases activation, thus decreasing the induction of proinflammatory cytokines following LPS, TNF-α, and IL-1β stimulation.

2002年2月15日 · Deletion of the COOH-terminal 86 amino acids in TAB1 [TAB1 (1-418)] increased its binding affinity for p38α and enhanced p38α phosphorylation (Fig. 4). Recombinant TAB1 (1-418) also efficiently activated p38α in vitro (11).

2016年1月10日 · AmphiTAB1 gene was involved in the innate immune response of LPS stimulation. AmphiTAB1 protein expressed in vitro shows a band with a molecular mass of 80 kDa and Western blot confirmed it.

2022年11月30日 · We identified the role of miR-146a-5p in inhibiting inflammatory response and promoting proliferation under lipopolysaccharide (LPS) stimulation in vitro and vivo. LPS stimulation significantly increased the expression of TNF …

2015年8月4日 · In this study, we identified a member of the deubiquitinases family, ubiquitin-specific protease 18 (USP18), as a novel negative regulator in Toll-like receptor (TLR)-mediated NF-κB activation in...

HMGB1 是一种能够结合 LPS 的损伤相关分子模式 (DAMP)，已被证明与 LPS 的细胞内转运有关（The endotoxin delivery protein HMGB1 mediates caspase-11-dependent lethality in sepsis. Immunity）。 尽管如此，游离 LPS 易位到细胞质中并在体内激活非经典炎性体的机制大多仍然难 …

2010年9月3日 · LPS or TNF-α signaling activate TAK1 by causing the association of TAK1 binding protein 1 (TAB1) with TAK1. Figure 3 H shows that LPS stimulation of RAW 264.7 cells causes TAB1/TAK1 association. DHA treatment leads to the association of β-arrestin2 with TAB1 (Figure 3 G) and largely blocks TAK1/TAB1 association (Figure 3 H).

Transforming growth factor-β-activating kinase 1 (TAK1) is triggered by foreign pathogenic infection and involves in proinflammatory response through the activation of nuclear factor-κB (NF-κB), which is specifically regulated by TAK1-binding protein 1 (TAB1).