Irgm1 (LRG-47), a regulator of cell-autonomous immunity, does …
2013年8月15日 · The IFN-inducible protein Irgm1 (LRG-47) belongs to the family of immunity-related GTPases that function in cell-autonomous resistance against intracellular pathogens in …
The p47 GTPase Lrg-47 (Irgm1) Links Host Defense and ... - Cell …
2008年1月10日 · We report that the interferon-inducible GTPase Lrg-47 (Irgm1), previously shown to play a critical role in host defense, inhibits baseline HSC proliferation and is required for a …
Immune control of tuberculosis by IFN-gamma-inducible LRG-47
2003年10月24日 · Here, we identify one member of a newly emerging 47-kilodalton (p47) guanosine triphosphatase family, LRG-47, that acts independently of NOS2 to protect against …
Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47 | Science …
2003年10月24日 · Here, we identify one member of a newly emerging 47-kilodalton (p47) guanosine triphosphatase family, LRG-47, that acts independently of NOS2 to protect against …
IRGM/Irgm1的生物学功能研究进展 - 国际免疫学杂志
小鼠Irgm1是一个分子量为47 000的干扰素(interferon，IFN)-γ诱导性免疫相关的GTP酶蛋白，广泛表达于细胞内的高尔基体或者内质网上 。小鼠Irgm1率先被证实参与抗寄生虫或抗菌感染治疗 …
Human IRGM Induces Autophagy to Eliminate Intracellular …
2006年9月8日 · We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism for the elimination …
Inactivation of LRG-47 and IRG-47 reveals a family of ... - PubMed
2001年7月16日 · After infection with L. monocytogenes, LRG-47-deficient mice exhibited a profound loss of resistance, whereas IRG-47-deficient mice exhibited completely normal …
Mechanisms Regulating the Positioning of Mouse p47 Resistance …
2004年8月15日 · In this study, we show that LRG-47 is a Golgi-associated protein in the IFN-stimulated cell, which is rapidly recruited to active plasma membrane upon phagocytosis and …
Mice Deficient in LRG-47 Display Increased Susceptibility to ...
2004年1月15日 · LRG-47 −/− and control B6129 animals (n = 4 mice/group) were infected aerogenically with 100 CFU of M. tuberculosis (Erdman strain), and pulmonary bacterial loads …
Inactivation of Lrg-47 and Irg-47 Reveals a Family of Interferon γ ...
LRG-47 and IRG-47 belong to a family of IFN-γ–induced proteins whose expression is increased to very high levels in mice after infection with numerous pathogens, including T. gondii, L. …
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