Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster of differentiation 91 (CD91), is a protein forming a receptor found in the plasma membrane of …

2024年12月25日 · LRP1 (LDL Receptor Related Protein 1) is a Protein Coding gene. Diseases associated with LRP1 include Developmental Dysplasia Of The Hip 3 and Keratosis Pilaris Atrophicans. Among its related pathways are Visual phototransduction and Statin inhibition of cholesterol production.

4月1日，在Nature上发表的一篇论文中，Kosik教授和他的团队揭示了tau蛋白在神经元之间的一种扩散机制： 低密度脂蛋白受体相关蛋白1 (low-denisity lipoprotein receptor-related protein 1，LRP1)作为这一过程的主要参与者，可以控制tau蛋白的内吞及其在神经元之间的扩散。这一 ...

2014年11月6日 · 载脂蛋白E (apolopoprotein,ApoE) [2] 与低密度脂蛋白受体相关蛋白1 (low-density lipoprotein receptor-related protein 1,LRP1) [3] 均对脑内Aβ的清除起到重要作用。 1 概述. LRP1是一种内吞受体，属于低密度脂蛋白 (low-density lipoprotein,LDL)受体家族成员。 这类受体家族的成员都是细胞表面受体并参胆固醇代谢、胞内运输及细胞信号传导等过程，且在突触可塑性和神经元发育方面起到重要作用。 LRP1的分子量为600 kDa，它能够结合约40种功能和结构 …

2025年1月26日 · Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional endocytic receptor whose dysfunction is linked to developmental dysplasia of...

2020年4月1日 · Here we show that the low-density lipoprotein receptor-related protein 1 (LRP1) controls the endocytosis of tau and its subsequent spread. Knockdown of LRP1 significantly reduced tau...

2021年7月1日 · Low-density lipoprotein (LDL) receptor-related protein-1 (LRP1), a transmembrane receptor protein belonging to the LDL receptor family, plays multifunctional roles in maintaining endocytosis, homeostasis, and signal transduction.

2022年9月2日 · We identified LRP1 as a key regulator of α-Syn neuronal uptake, as well as an important mediator of α-Syn spread in the brain. This study provides new knowledge on the physiological and pathological role of LRP1 in α-Syn trafficking and pathology, offering insight for the treatment of synucleinopath …

LDL receptor-related protein 1 (LRP1) is a multi-functional protein with endocytic and signal transduction properties due to its interaction with numerous extracellular ligands and intracellular proteins. This brief review highlights key ...

2014年12月10日 · Low-density lipoprotein (LDL)-related protein-1 (LRP-1) is a member of LDL receptor family that is implicated in lipoprotein metabolism and in the homeostasis of proteases and protease inhibitors. Expression of LRP-1 is ubiquitous. Up-regulation of LRP-1 has been reported in numerous human diseases.