OTUD7B去泛素化LSD1以控制其结合伴侣蛋白的特异性、体内平衡 …
已知赖氨酸特异性去甲基化酶1 (LSD1) 通过与CoREST/ 组蛋白去乙酰化酶 (HDAC) 形成抑制蛋白复合物来执行表观遗传调控。 然而，细胞维持LSD1/CoREST复合体完整性的分子机制尚不清 …
OTUD7B Deubiquitinates LSD1 to Govern Its ... - Wiley Online Library
2021年5月29日 · OTUD7B is responsible for LSD1 deubiquitination at K226/277 residues, resulting in dynamic control of LSD1 binding partner specificity and cellular homeostasis. …
Strategies that regulate LSD1 for novel therapeutics
2024年4月1日 · LSD1 can remove methyl groups from histone 3 at lysine 4 or lysine 9 (H3K4 or H3K9), resulting in either transcription repression or activation. While the roles of LSD1 in …
Targeting lysine-specific histone demethylase 1A (LSD1) can improve tumor immunogenicity of poorly immu-nogenic tumors, such as non-small cell lung cancer (NSCLC), with elevated T cell …
Lactylation of LSD1 is an acquired epigenetic ... - ScienceDirect
2025年3月24日 · Here, we identified TRIM21 as a direct upstream E3 ligase of LSD1, catalyzing its K63-linked ubiquitination, which in turn promoted its interaction with p62, a Ub receptor …
Nature子刊：LSD1 在调节增强子和细胞命运转变中的独立去甲基 …
LSD1是转录共抑制复合物CoREST的一个组成部分，该复合物包含接头蛋白 RCOR1 和组蛋白脱乙酰酶 HDAC1 和 HDAC2。 RCOR1直接与HDAC1/2和LSD1相互作用，将两个酶部分桥接成 …
Protein degradation of Lsd1 is mediated by Bre1 yet opposed by
2024年5月17日 · We discovered that Lsd1 protein stability is regulated by ubiquitin-proteasome system (UPS) during fly follicle development. Through genetic and biochemical means, an E3 …
Histone demethylase LSD1 promotes RIG-I poly-ubiquitination …
2021年9月16日 · LSD1 is a histone demethylase regulating transcription. The current study reveals a novel function of LSD1 in regulating the activation of RIG-I signaling pathway. LSD1 …
A state-of-the-art review on LSD1 and its inhibitors in breast …
Lysine-specific demethylase 1 (LSD1), a first identified histone demethylase, mediates the removal of methyl groups from histones H3K4me1/2 and H3K9me1/2 and plays a crucial role …
LSD1 Ablation Stimulates Anti-tumor Immunity and Enables …
Ablating the histone demethylase LSD1 genetically or pharmacologically enhances tumor immunogenicity by stimulating endogenous retrovirus expression and downregulating RNA …