Leukotriene B4 (LTB4) is a major type of lipid mediator that is rapidly generated from arachidonic acid through sequential action of 5-lipoxygenase (5-LO), 5-lipoxygenase-activating protein (FLAP) and LTA4 hydrolase (LTA4H) in response to various stimuli.

Leukotriene B 4 (LTB4) is a proinflammatory lipid mediator generated from arachidonic acid through the sequential activities of 5–lipoxygenase, 5–lipoxygenase–activating protein, and leukotriene A 4 hydrolase 16.

LTB4 is a potent chemoattractant, facilitating leukocyte adhesion and recruitment and its role in the pathogenesis of atherosclerosis is well established. LTA4 can be conjugated with glutathione through the enzyme LTC4 synthase to produce Leukotriene C4 (LTC4).

Leukotriene B4 is a leukotriene composed of (6Z,8E,10E,14Z)-icosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. It is a lipid mediator of inflammation that is generated from arachidonic acid via the 5-lipoxygenase pathway. It has a role as a human metabolite, a mouse metabolite, a plant metabolite and a vasoconstrictor agent.

Leukotriene B 4 (LTB 4) is an endogenous lipid mediator of inflammation derived from arachidonic acid by the sequential action of cytosolic phospholipase A 2 and 5-lipoxygenase. This mediator was initially recognized for its involvement in the recruitment of neutrophils.

Aug 1, 2020 · Leukotriene B4 (LTB4) is a major type of lipid mediator that is rapidly generated from arachidonic acid through sequential action of 5-lipoxygenase (5-LO), 5-lipoxygenase-activating protein (FLAP) and LTA4 hydrolase (LTA4H) in response to various stimuli.

Mar 3, 2022 · Leukotriene B4 receptor 1 (BLT1) plays crucial roles in the acute inflammatory responses and is a valuable target for anti-inflammation treatment, however, the mechanism by which...

Leukotriene B 4 (LTB 4), a lipid mediator produced from arachidonic acid, is a chemoattractant for inflammatory leukocytes. We identified two receptors for LTB 4, the high-affinity receptor BLT1 and the low-affinity receptor BLT2.

Aug 1, 2023 · Leukotriene B 4 (LTB 4) is a potent lipid chemoattractant driving inflammatory responses during host defense, allergy, autoimmune and metabolic diseases. Gradients of LTB 4 orchestrate...

Directed leukocyte migration is a hallmark of inflammatory immune responses. Leukotrienes are derived from arachidonic acid and represent a class of potent lipid mediators of leukocyte migration. In this review, we summarize the essential steps leading to the production of LTB 4 …

May 15, 2012 · Leukotriene B4 (LTB4) is a potent chemoattractant secreted by neutrophils in response to formyl peptides. We demonstrate that LTB4 significantly amplifies neutrophil recruitment to primary chemoattractants by selectively modulating signaling cascades involved in cell polarization and by serving as a potent secondary gradient.

Aug 8, 2024 · S100A10 may activate the cPLA2 and 5-LOX axis, initiating lipid metabolism reprogramming and upregulating LTB4 levels, thus promoting CD8 + T cell exhaustion in HCC tissues, facilitating immune...

We studied the role of the eicosanoid leukotriene B4 (LTB4) in OM. Expression of LTB4-related genes was evaluated by gene array and single-cell RNA-Seq in MEs infected with nontypeable Haemophilus influenzae (NTHi). An inhibitor of LTB4 receptor 1 (i.e. U75302) was also used to block LTB4 responses.

Aug 8, 2024 · S100A10 may activate the cPLA2 and 5-LOX axis, initiating lipid metabolism reprogramming and upregulating LTB4 levels, thus promoting CD8 + T cell exhaustion in HCC tissues, facilitating immune evasion by HCC cells, ultimately impacting the growth and migration of …

Jan 1, 2020 · Leukotriene B 4 (LTB 4), a lipid mediator derived from arachidonic acid, is a chemoattractant for inflammatory leukocytes. We previously identified two receptors for LTB 4, the high-affinity receptor BLT1 (LTB4R1) and the low-affinity receptor BLT2 (LTB4R2), which are highly conserved among species.

LTB4 mediates multiple biological functions through its interaction with two distinct receptors, LTB4 receptor 1 (BLT1) and LTB4 receptor 2 (BLT2). Although LTB4 was one of the earliest leukocyte chemoattractants identified, characterization of the receptors was more difficult.

We show that LTB 4 production dramatically amplifies formyl-peptide-mediated neutrophil polarization and chemotaxis by regulating specific signaling pathways acting upstream of actin polymerization and MyoII phosphorylation.

Ultrastructural analysis of pyroptotic body, the levels of interleukin (IL)-1β, IL-18, IL-33, MIP-2, CXCL8, reactive oxygen species (ROS), and LTB4 were measured with ELISA. Results: Our results showed that septic rats had impaired hepatic function and ET-1 levels.

Given the relevance obtained in proving the role played by LTB4 in the context of obesity and IR, in the current article we focus on evidence that shows LTB4 acting on inflammation developed due to HFD-induced obesity, along with the potential strategies used to mitigate the connection between LTB4-LTB4R1.

LTB4 is the effector molecule that induces CD8 + T cell exhaustion by S100A10. Previous studies have shown that the upregulation of S100A10 in HCC cells may lead to an increase in the levels of leukotriene B4 (LTB4), which has been proven to be a pro-inflammatory factor .