LTB4是最有效的炎症介导脂类之一。 白三烯的合成不需要成环，所以叫线性途径。 催化线性途径的是花生四烯酸脂加氧酶（LOX），共有三种：5-LOX，12-LOX和15-LOX。 产生白三烯的是5-LOX。 12-LOX和15-LOX用于合成脂氧素。 白三烯的合成。 引自themedicalbiochemistrypage. 脂氧素（LX）也是线性分子，含有三个羟基和四个共轭双键。 它与白三烯外形相似，功能相反，是有效的抗炎性类花生酸，并可抵消促炎性类花生酸的作用（主要是LTB 4、PGE 2和TXA 2） …

Ebselen is a selenorganic compound that mimics and induces glutathione peroxidase (GPx) activity and is effective in reducing neuroinflammation across the central and peripheral nervous system. GPx activity is critical to several cell types and tissues in the inner ear, retina, prefrontal cortex of brain, lung, and kidney, and is often reduced ...

2017年10月1日 · Leukotriene B 4 (LTB 4), a lipid mediator produced from arachidonic acid, is a chemoattractant for inflammatory leukocytes. We identified two receptors for LTB 4, the high-affinity receptor BLT1 and the low-affinity receptor BLT2.

Leukotriene B4 is a leukotriene composed of (6Z,8E,10E,14Z)-icosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. It is a lipid mediator of inflammation that is generated from arachidonic acid via the 5-lipoxygenase pathway. It has a role as a human metabolite, a mouse metabolite, a plant metabolite and a vasoconstrictor agent.

白三烯b4（ltb4）在先天免疫中起着重要作用，因为它诱导吞噬细胞募集，抗菌效应物的释放，并增强病原体的摄取和杀灭。在人类中，ltb4的半衰期短，并且被白细胞迅速代谢，特别是被嗜中性粒细胞代谢为20-oh-和20-cooh-ltb4。

该课题组发现LPS诱导的急性肺损伤小鼠的支气管肺泡灌洗液中LTB4持续增高，其功能性受体BLT1高表达于激活的Treg细胞，而不是静息Treg细胞。

白三烯B4（LTB4）主要由 中性粒细胞 产生；LTC4由肥大细胞、 嗜酸性粒细胞 和 嗜碱性粒细胞 产生，而 单核细胞 、巨噬细胞通过脂氧代谢途径既产生LTB4又产生LTC4。

生物活性：白三烯 b4 (ltb4) 被认为是最有效的化学引诱剂和白细胞激活剂之一，与炎症性疾病有关。白三烯 b4 也是一种基于烷基链的 protac 接头，可用于 protac 的合成[1][2][3] .

Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

结论 :LTB4-BLT1通路可能分别通过直接作用于ILC2s或/和间接诱导IL-33的分泌作用于ILC2s,影响其迁移和活化,最终影响气道过敏性炎症的免疫应答发生和炎症的发展。