Along with medical history, symptom assessment, and physical examination, the following laboratory tests are recommended as part of the initial evaluation in the diagnostic workup of MPNs: CBC, peripheral blood smear, comprehensive metabolic panel (CMP) (including uric acid, lactate dehydrogenase [LDH], and liver function tests [LFTs]), serum er...

Myeloproliferative neoplasms (MPN) and myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are clonal disorders arising from hematopoietic stem cells with altered proliferation and maturation. The diagnosis and classification of these neoplasms is based on a variety of clinical and pathologic characteristics, including the presence of ...

Myeloproliferative Neoplasms (MPN) Core Diagnostic Panel - The MPN Core Diagnostic panel is an evidence-based, disease targeted mutational analysis panel, performed by Next-generation sequencing (NGS).

Important hematological malignancies to consider include myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN). MDS and MPN are cancers that impact the volume of certain types of blood cells.

Molecular testing of blood or bone marrow is useful in the evaluation of suspected myeloproliferative neoplasms (MPN). Mutations in the JAK2, MPL and CALR genes are present in virtually all MPNs and their presence help distinguish …

IntelliGEN® Myeloid utilizes amplicon-based next generation sequencing to identify alterations in 50 genes that have diagnostic, prognostic, and therapeutic significance in myeloid neoplasms.

Myeloproliferative Neoplasms (MPN) Mini Panel - The MPN mini profile detects disease-defining, potentially targetable mutations in JAK2, CALR, and MPL for myeloproliferative neoplasms. These 3 genes are growth- promoting oncogenes that operate through a signaling pathway mediated by JAK2, and MPNs with these mutations can respond to clinically ...

LeukoVantage®, Myeloproliferative Neoplasms (MPN) - This test is designed to aid in diagnosis, prognosis and/or treatment strategy for patients with MPN.

Myeloproliferative neoplasms (MPN) occur when the bone marrow, the spongy tissue inside the large bones in the body, makes too many blood cells. These cancers are sorted based on which type of blood cell is overproduced: red blood cells, white blood cells, or platelets.

Myeloproliferative neoplasms (MPNs) are a subset of bone marrow disorders. They are a group of diseases characterised by the production of too many of one or more types of blood cells in the bone marrow. Laboratory tests can be used to help diagnose and monitor MPNs.