LAMP3 is a Type I integral membrane protein consisting of about 416 amino acid residues with about 90% of the protein located within the lumen of the lysosomes. [9] LAMP3 has been shown to be highly expressed in dendritic cells during cell differentiation and maturation. [7]

2024年12月25日 · LAMP3 (Lysosomal Associated Membrane Protein 3) is a Protein Coding gene. Diseases associated with LAMP3 include Mumps and Rem Sleep Behavior Disorder. Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction (PubMed: 25681212).

2025年2月8日 · LAMP3 is a potent uterine corpus endometrial carcinoma prognostic biomarker associated with immune behavior. Inhibition of LAMP3 mediates the protective effect of vitamin D against hypoxia/reoxygenation in trophoblast cells.

Selective cytoplasmic expression in type II pneumocytes and lymphoid non-germinal center cells. Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.

LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization Autophagy . 2022 Jul;18(7):1629-1647. doi: 10.1080/15548627.2021.1995150.

LAMP3 expression is linked with poor prognosis of certain cancers, and the locus where it is encoded was identified as a risk factor for Parkinson's disease (PD). Here, we investigated the role of LAMP3 in the two main cellular degradation pathways, the proteasome and autophagy.

LAMP-3, also known as DC-LAMP/CD208, is a member of the LAMP family of proteins, but its role during Salmonella infection remains unclear. DNA microarray analysis identified LAMP-3 as one of the genes responding to LPS stimulation in THP-1 macrophage cells.

Lysosome-associated membrane protein 3 (LAMP3) was first identified as a cell surface marker of mature dendritic cells and specifically expressed in lung tissues. Recently studies demonstrated that LAMP3 plays a critical role in several cancers, and regulated by hypoxia.

Compared to healthy controls, LAMP3 expression was upregulated in the transcriptional profiles of the liver in patients with CHB. The high LAMP3 expression was related to T cell activation and the chemokine signaling pathway.

2020年9月16日 · This study defines a clear role for LAMP3 in the initiation of apoptosis and an independent pathway for the extracellular release of known autoantigens leading to the formation of autoantibodies...