2016年2月29日 · The large HSPs complexed with self-antigens can be captured by professional antigen-presenting cells (APCs) through scavenger receptor (SR)-mediated endocytosis. Large HSP-based chaperoning enhances the cross-presentation of associated antigens and activation of self-reactive CD8 + T cells.

2025年3月12日 · Large heat shock proteins (large HSPs) are highly expressed when stimulated by cytotoxic or proteotoxic stresses. HSP110 is a large HSP that has been well characterized in mammals.

2008年9月2日 · Based on molecular weight, Hsps can be categorized into several families, including Hsp90, Hsp70, Hsp60, Hsp40 (so-called large Hsps) and small Hsps (sHsps, with the molecular weights varying...

The large stress proteins, Hsp110 and Grp170, exhibit structural similarities as well as differences from Hsp70. Early studies suggest an important role for these large stress proteins in collaboration with smaller HSPs and GRPs in protection from heat shock and chronic ischemia.

2017年3月1日 · Heat shock proteins (HSPs) constitute a large family of proteins involved in protein folding and maturation whose expression is induced by heat shock or other stressors. The major groups are classified based on their molecular weights and include HSP27, HSP40, HSP60, HSP70, HSP90, and large HSPs.

2023年11月15日 · Based on their molecular weight, Hsps can be divided into six families: small Hsps, Hsp40, Hsp60, Hsp70, Hsp90, and large Hsps. In the process of breast cancer tumorigenesis, Hsps play a central role in regulating cell reactions and functions including proliferation, metastasis, and apoptosis.

2021年1月1日 · HSP expression is induced by heat shock or other stressors including cellular damage and hypoxia. The major groups, which are classified based on their molecular weight, include HSP27, HSP40, HSP60, HSP70, HSP90, and …

2020年1月18日 · HSP70 and HSP90 are the most studied HSPs in this very large HSP family. Notably, HSP90 also stabilizes the disease-related proteins in neurodegenerative disorders. Therefore, small molecules that inhibit the HSP90 but also increase the HSP70 has been tested as potential drugs for neurodegenerative disorders.

Here, we review the current advances in understanding these large HSPs as molecular chaperones in proteostasis control and immune modulation as well as their therapeutic implications in treatment of cancer and neurodegeneration.

Based on molecular weight, Hsps can be categorized into several families, including Hsp90, Hsp70, Hsp60, Hsp40 (so-called large Hsps) and small Hsps (sHsps, with the molecular weights varying...