周强组解析首个人源氨基酸转运体LAT1–4F2hc复合体结构_光谱网
5 天之前 · 2019年3月14日，西湖大学生物学研究所周强研究员团队在Nature发表了题为Structure of the human LAT1–4F2hc heteromeric amino acid transporter complex的论文（第一单位为清 …
LAT1 - Transporters - Solvo Biotechnology
Like all members of the heteromeric amino acid transporter (HAT, SLC7) family, LAT1 resides in the plasma membrane in a heterodimeric form. The LAT1 holotransporter consists of a 55-kDa …
Structural basis for the substrate recognition and transport ... - AAAS
6 天之前 · Heteromeric amino acid transporters (HATs), including y + LAT1-4F2hc complex, are responsible for transporting amino acids across membranes, and mutations in y + LAT1 cause …
Yeast Cell-Based Transport Assay for the Functional …
The HAT 4F2hc-LAT1 is found upregulated in various cancer cell types, while 4F2hc-LAT2 is a transporter for non-cancer cells. Preclinical studies have highlighted that 4F2hc-LAT1 plays an …
L-Type amino acid transporter 1 as a target for drug delivery
Due to the significant up-regulation of LAT1 expression in several human tumors, LAT1 has been an attractive transporter for targeted delivery of amino acid-derived anticancer drugs and …
Mechanism of substrate transport and inhibition of the human LAT1 …
2021年3月23日 · LAT1 (SLC7A5) is one of the representative light chain proteins of heteromeric amino acid transporters, forming a heterodimer with its heavy chain partner 4F2hc (SLC3A2). …
The Role of Large Neutral Amino Acid Transporter (LAT1) in Cancer
LAT1 (also known as SLC7A5), is defined as a heteromeric amino acid transporter (HAT) interacting with the glycoprotein CD98 (SLC3A2) through a conserved disulfide to uptake not …
LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed …
2019年7月7日 · Among the solute carriers, heteromeric amino-acid transporters (HATs) are unique in their quaternary structure. LAT1–CD98hc, a HAT, transports essential amino acids …
异源寡聚氨基酸转运蛋白复合体的结构与功能新见解 - 生物通
4 天之前 · HATs家族由轻链和重链组成，通过二硫键连接，能够运输氨基酸、多胺和药物等物质。y + LAT1-4F2hc复合体是HATs家族的典型成员，其轻链y + LAT1负责底物特异性和运输活性， …
氨基酸转运载体LAT1研究进展-【维普期刊官网】- 中文期刊服务平台
L-type amino acid transporter-1 （LAT1） is a member of the sodium-independent amino acid transport system L and transports large branched-chain and aromatic neutral amino acids. …
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