Tyrosin-protein kinase Lck (or lymphocyte-specific protein tyrosine kinase) is a 56 kDa protein that is found inside lymphocytes and encoded in the human by the LCK gene. [5] The Lck is a member of Src kinase family (SKF) and is important for the activation of T-cell receptor (TCR) signaling in both naive T cells and effector T cells.

2024年12月25日 · LCK (LCK Proto-Oncogene, Src Family Tyrosine Kinase) is a Protein Coding gene. Diseases associated with LCK include Immunodeficiency 22 and Severe Combined Immunodeficiency. Among its related pathways are CD28 co-stimulation and Constitutive Signaling by Aberrant PI3K in Cancer.

蛋白激酶Lck可以将胞外抗原识别输入转换为TCR磷酸化信号输出，即Lck可以磷酸化免疫受体酪氨酸激活模体ITAMs中的酪氨酸残基，进而招募效应激酶Zap70，并将Zap70磷酸化激活，从而引起下游Lat等调控因子执行T细胞应答反应。

1997年4月8日 · Lck is a Src-family tyrosine kinase expressed in T lymphocytes, where it participates in the cellular immune response. Like all Src homologues, it comprises SH3, SH2 and kinase domains. Lck associates through its distinctive amino-terminal segment with the cytoplasmic tails of either T-cell co-receptor, CD4 or CD8-alpha.

2017年10月30日 · LCK is a tyrosine kinase that is essential for initiating T-cell antigen receptor (TCR) signaling. A complete understanding of LCK function is constrained by a paucity of methods to...

2001年3月1日 · Lck, a Src family protein tyrosine kinase (PTKs), is post-translationally modified by palmitoylation, a process thought to regulate the biological function, membrane affinity and glycolipid-enriched microdomain (GEM) localization of this molecule.

2012年6月18日 · Lck is bound to the plasma membrane via myristoylated and palmitoylated residues at its N-terminus. It also contains a SH3 and a SH2 domains next to the membrane anchor followed by a catalytic tyrosine kinase domain and a short C-terminal tail.

2014年6月29日 · More recently, a new target was found for Lck: the protein Nck (Vázquez, 2007), consisting of one SH2 domain and three SH3 domains, which is known to link receptor tyrosine kinases to downstream proteins, and to be active in actin polymerization. It was also reported that Nck binds in T cells to the CD3 subunit of the T-cell antigen receptor ...

1994年12月12日 · The kinase p56lck (Lck) is a T-lymphocyte-specific member of the Src family of non-receptor tyrosine kinases. Members of the Src family each contain unique amino-terminal regions, followed by Src-homology domains SH3 and SH2, and a tyrosine kinase domain. SH3 and SH2 domains mediate critical protein interactions in many signal-transducing pathways.

The protein p56lck (Lck) is a Src-like, lymphocyte-specific tyrosine kinase. A phosphopeptide library screen has recently been used to deduce an 'optimal' binding sequence for the Lck SH2 domain. There is selectivity for the residues Glu, Glu and Ile in the three positions C-terminal to the phosphotyrosine.