Lck, a member of the Src kinase family, is a non-receptor tyrosine kinase involved in immune cell activation, antigen recognition, tumor growth, and cytotoxic response. The enzyme has usually …

共受体分子如CD4/CD8被报道可以结合LCK（coreceptor-associated LCK），促进LCK激活。 然而，CD4/CD8的缺失并不阻碍T细胞的发育活化，只影响MHC特异性的T细胞识别，提示LCK …

In recent years, the lymphocyte-specific protein tyrosine kinase (Lck) has emerged as one of the key molecules regulating T-cell functions. Studies using Lck knock-out mice or Lck-deficient T …

2021年6月11日 · Integrative gene expression analysis identified the Lymphocyte cell-specific protein-tyrosine kinase (LCK) as a druggable target gene associated with cancer cell invasion …

2022年12月23日 · Overall, our findings reveal the role of co-receptor-bound LCK in T cell biology, show that CD4- and CD8-bound LCK drive T cell development and effector immune responses …

2024年7月24日 · Lck, a member of the Src kinase family, is a non-receptor tyrosine kinase involved in immune cell activation, antigen recognition, tumor growth, and cytotoxic response. …

2022年11月13日 · In this study, pan-cancer analysis based on a variety of databases was used to explore the role of LCK in human tumors, including their occurrence, development, …

2019年7月16日 · In recent years, the lymphocyte-specific protein tyrosine kinase (Lck) has emerged as one of the key molecules regulating T-cell functions. Studies using Lck knock-out …

2018年12月1日 · Lck is an essential early mediator of the TCR signaling pathway. Lck, a non-receptor src family kinase, plays a vital role in various cellular processes such as cell cycle …

2024年7月24日 · In colorectal cancer, Lck is expressed in some human colon carcinoma cell lines and is found at low levels in normal colonic epithelial cells, with its upregulation potentially …