Cholesterol-Lowering Gene Therapy Counteracts the Development …
2017年11月1日 · AAV8 -LDLr gene therapy attenuated cardiac hypertrophy, reduced interstitial and perivascular fibrosis, and decreased lung congestion in TAC mice.
A covalent peptide-based lysosome-targeting protein ... - Nature
2025年2月6日 · Biological experiments demonstrate that covalent Pep-TACs can significantly degrade the expression of PD-L1 on tumor cells, dendritic cells and macrophages, especially …
Cholesterol lowering attenuates pressure overload-induced heart …
2019年9月9日 · The principal findings of the current study are that (1) cholesterol lowering gene therapy in C57BL/6 LDLr-/-mice with only mild hypercholesterolemia significantly decreased …
Cholesterol-Lowering Gene Therapy Counteracts the Development …
2017年11月1日 · AAV8-LDLr gene therapy attenuated cardiac hypertrophy, reduced interstitial and perivascular fibrosis, and decreased lung congestion in TAC mice. Cardiac function, …
Mouse models of atherosclerosis and their suitability for the study …
The types and locations of lesions in LDLR −/− mice are similar to ApoE −/− mice, and build up gradually with the earliest lesions seen in the proximal aorta. In general, the LDLR −/− model …
基于共价肽的肿瘤免疫治疗溶酶体靶向蛋白降解平台 - 生物通
2025年2月7日 · 为了扩充有限的用于 TPD 的溶酶体穿梭受体库，研究人员利用癌症基因组图谱（TCGA）的数据，检测并比较了多种溶酶体靶向受体（LTRs），包括甘露糖 - 6 - 磷酸受 …
Total and non-HDL, VLDL, IDL, LDL, and HDL plasma cholesterol …
In this study, our aim was to quantify coronary atherosclerosis and artery remodeling following transverse aortic constriction (TAC) in C57BL/6N apo E−/− mice and to evaluate the impact of...
Representative Sirius red-stained cross-sections of non …
The objective of the current study was to evaluate the effect of selective cholesterol lowering adeno-associated viral serotype 8 (AAV8)-mediated low-density lipoprotein receptor (LDLr) …
Cholesterol lowering attenuates pressure overload-induced heart …
2019年9月4日 · Cholesterol lowering gene therapy counteracted myocardial oxidative stress and preserved the potential for myocardial fatty acid oxidation in TAC mice. In conclusion, …
金合欢素的降血脂及抗动脉粥样硬化作用及机制初探
降低ldl-c是目前临床治疗动脉粥样硬化性心血管病的主要干预靶点, 他汀类药物就是反馈上调细胞表面ldlr, 使血浆胆固醇水平降低。在前期研究中, 本课题组发现田蓟苷作用动脉粥样硬化模型大 …