Anti-LDL Receptor antibody [EP1553Y] - Abcam
Anti-LDL receptor antibody [EP1553Y] is a rabbit recombinant monoclonal antibody designed to detect the low-density lipoprotein receptor (LDLR). Validated for western blot (WB) and …
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重组Anti-LDL Receptor抗体[EP1553Y] (ab52818) - Abcam中文官网
购买经敲除验证的重组LDL Receptor兔单克隆抗体 [EP1553Y] (ab52818)，LDL Receptor抗体经WB验证，可与人,小鼠样本反应。 145篇文献引用，16个独立用户反馈。
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LDLR antibody (66414-1-Ig) | Proteintech - ptglab
The cytoplasmic domain of the LDL receptor is necessary for the receptor to cluster in coated pits, which promotes the rapid endocytosis of bound LDL. The protein is highly glycosylated …
Anti-LDL Receptor antibody. Rabbit polyclonal (ab30532) | Abcam
Anti-LDLR antibody is a rabbit polyclonal antibody that is used in LDL receptor western blot (WB), IHC, and immunocytochemistry/immunofluorescence (ICC/IF). Suitable for mouse, human and …
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Dysregulation of the Low-Density Lipoprotein Receptor Pathway Is ...
As a key cell surface receptor for cholesterol uptake and traffic, low-density lipoprotein receptor (LDLR) is susceptible to be attacked by detrimental factors. The LDLR regulates the …
Proteolysis of the low density lipoprotein receptor by bone ...
2019年8月6日 · The 120 kDa CTF was detected in the livers from humans and mice expressing human LDLR. Collectively, these results identify that BMP1 regulates cellular LDL uptake and …
Human LDLR Antibody - R&D Systems
Detects human LDL R in direct ELISAs and Western blots. In direct ELISAs, approximately 15% cross-reactivity with recombinant mouse LDL R is observed. Polyclonal Goat IgG. Antigen …
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Frontiers | Cellular and functional evaluation of LDLR missense ...
2024年7月23日 · Like other secretory and endomembrane proteins, nascent LDLR is initially synthesized in the ER as an immature protein with a molecular weight of ∼120 KDa and is …
Low-Density Lipoprotein Receptor-Related Protein 8 at the …
The main well-known LDLR ligand is represented by apolipoprotein E (ApoE), a 34 kDa soluble protein that is a main component of lipoproteins in plasma and a secreted glycoprotein of 34 …
Anti-LDL Receptor抗体(ab30532) - Abcam中文官网
Use at an assay dependent concentration. Predicted molecular weight: 95 kDa. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In …
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Novel Tools for Comprehensive Functional Analysis of LDLR (Low …
2023年7月14日 · The low-density lipoprotein (LDL) receptor (LDLR) is a membrane glycoprotein with a molecular mass of 160 kDa, that mediates the uptake of lipoprotein particles, mainly …
The low-density lipoprotein receptor: Emerging post …
2024年9月15日 · Hepatic LDLR abundance is a central determinant of lipoprotein clearance. Dysregulation of the LDLR pathway is associated with hypercholesterolemia and development …
LDLR 蛋白, Mouse (HEK293, His) - MCE
LDLR 蛋白与 LDL 关键结合，通过内吞作用转运胆固醇。 聚集成网格蛋白包被的小凹坑启动内化。 与 DAB2、LDLRAP1、ARRB1、SNX17 和不成熟的 PCSK9 的相互作用有助于其功能的 …
PCSK9-mediated degradation of the LDL receptor generates a 17 kDa …
Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the LDL receptor (LDLR) at the cell surface and reroutes the internalized LDLR to intracellular degradation. In this study, we have …
The LDL receptor: how acid pulls the trigger - Cell Press
The low-density lipoprotein receptor (LDLR) is responsible for transporting cholesterol-containing lipoprotein particles from the circulation into cells. Patients with loss-of-function mutations in …
Mutations affecting the transmembrane domain of the LDL …
2017年2月22日 · To study the impact of mutations affecting the hydrophobic transmembrane domain of the LDLR, each of the 22 amino acids of the transmembrane domain was …
Functional profiling of LDLR variants: Important ... - ScienceDirect
2022年7月1日 · Relative band intensities of mature (≈160 kDa) and precursor (≈120 kDa) forms of LDLR protein were quantified by densitometric analysis using Image Lab Software (BioRad) …
PCSK9-mediated degradation of the LDL receptor generates a 17 kDa …
2012年11月25日 · Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the LDL receptor (LDLR) at the cell surface and reroutes the internalized LDLR to intracellular …
AFM reveals differential effects of acidification on LDL– and …
3 天之前 · This type of oxLDL can induce the formation of foam cells and therefore is widely used to study lipid metabolism and atherosclerosis. Recombinant human CD36, LDL receptor …
Immunotherapy and vaccine-based approaches for atherosclerosis ...
1 天前 · Introduction Cardiovascular disease is a major global health issue, and atherosclerosis is a leading cause of cardiovascular conditions. Traditional approaches for managing …