2000年10月27日 · We analyzed gene expression in the hypothalamic circadian clock, the suprachiasmatic nucleus (SCN), of behaviorally “split” hamsters housed in constant light. The results show that the two oscillators underlying the split condition correspond to the left and right sides of the bilaterally paired SCN.

2000年2月4日 · The SCN is a small, paired, wing-shaped structure in the hypothalamus, located at the base of the brain. The animation shows the isolated left SCN, optic nerve, and eye, while the right SCN is shown embedded within the hypothalamus in the brain.

The central circadian pacemaker of the suprachiasmatic nuclei (SCN) is a bilaterally symmetrical structure. Little is known about the physiological mechanisms underlying communication between the left and right SCN and yet the degree of synchronization between SCN neurons can have a critical impact …

2021年9月24日 · Here we identify a vascular pathway in mouse for communication of diffusible signals in a hypothalamic portal system connecting the SCN and a nearby circumventricular organ (CVO), namely the...

Ever since the locus of the brain clock in the suprachiasmatic nucleus (SCN) was first described, methods available have both enabled and encumbered our understanding of its nature at the level of the cell, the tissue and the animal. A combination of in vitro and in vivo approaches has shown that the SCN is a complex heterogeneous neuronal network.

The suprachiasmatic nucleus (SCN) is the primary circadian pacemaker in mammals. Individual SCN neurons in dispersed culture can generate independent circadian oscillations of clock gene expression and neuronal firing. However, SCN rhythmicity ...

2020年2月17日 · We have used single-cell RNA-sequencing to identify the basic cell types in the mouse SCN and to characterize their circadian and light-induced gene expression patterns. We identified eight major...

2020年9月30日 · Stimulation of the SCN region drives a variety of GABA and glutamate driven responses in downstream target neurons. a Schematic of typical ex vivo recording and stimulation configuration (left) and proportions of isolated neurons exhibiting various classes of response to electrical stimulation as a function of dorsal-ventral location (right; n.r...

The left SCN represents the neurochemical identity of the ventrolateral portion of the nuclei, in neurons that express clock genes in response to light and are directly innervated by the RHT, the...

2011年7月1日 · The suprachiasmatic nucleus (SCN) of the hypothalamus is the site of the master circadian pacemaker in mammals. The individual cells of the SCN are capable of functioning independently from one another and therefore must form a cohesive circadian network through intercellular coupling.