let-7 microRNA family - Wikipedia
The let-7 microRNA family refers to the many slight variations of let-7 that exist both within a single organism and across species. In humans, for example, there are ten unique let-7 family …
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Let-7家族对细胞“干性”的调控
对于高度同源的let-7家族成员会在let-7后加一个字母以示区分,例如let-7的基因簇2(cluster2)就是由let-7a、let-7d和let-7f基因组成的。 另外,来自染色体不同位置的pre-let-7 miRNA可以产生相同 …
Let-7 - 维基百科，自由的百科全书
let-7基因最早在线虫中被发现，是一种关键的发育调节因子，并成为已知的第两种 microRNA 之一（另一种是 lin-4）。 [1] 很快，"let-7"在果蝇中也被发现，并通过 BLAST （基本局部比对搜 …
The let-7 family of microRNAs - ScienceDirect
2008年10月1日 · Here, we review let-7 -family conservation and the recent advances in understanding how let-7 -expression is regulated at the transcriptional and post-transcriptional …
MicroRNA profiling and identification of let-7a as a target to …
2019年7月3日 · Our results revealed that several miRNAs are differently expressed during chemotherapy exposure. Amongst them, let-7a was the most profoundly downregulated and …
Visual and Electrochemical Detection of let-7a: A Tumor …
2023年5月29日 · Let-7a, a type of low-expressed microRNAs in cancer cells, has been investigated as a promising biomarker and therapeutic target for tumor suppression. …
A Regulator of Metabolic Reprogramming: MicroRNA Let-7
2019年7月1日 · Let-7 has emerged as a central regulator of systemic energy homeostasis and it displays remarkable plasticity in metabolic responses to nutrients availability and physiological …
let-7 microRNA是发现较早的一类miRNA, 最早在线虫中发现能调控细胞分裂的时序。 此后大量证据表明,let-7参与动物多个器官发育的调控过程, 并与人类疾病发生密切相关。 该文综述了近年 …
Biogenesis and regulation of the let-7 miRNAs and their functional ...
To generate a let-7 miRNA, a primary transcript is produced by RNA polymerase II and then subsequently processed by Drosha/DGCR8, TUTase, and Dicer. Because dysregulation of let …
MicroRNA-Let-7a regulates the function of microglia in inflammation
2015年9月1日 · MicroRNA-Let-7a (miR-Let-7a) is a tumor suppressor miRNA that has been reported to target transcripts that encode proteins involved in apoptosis. In the present study, …