2024年12月25日 · LGR5 (Leucine Rich Repeat Containing G Protein-Coupled Receptor 5) is a Protein Coding gene. Diseases associated with LGR5 include Ankyloglossia With Or Without Tooth Anomalies and Mesenteric Vascular Occlusion .

Symbol Description Category UniProt ID GIFtS GC id Score; 1: LGR5: Leucine Rich Repeat Containing G Protein-Coupled Receptor 5: Protein Coding: O75473: 56: GC12P071439

2024年12月25日 · LGR6 (Leucine Rich Repeat Containing G Protein-Coupled Receptor 6) is a Protein Coding gene. Diseases associated with LGR6 include Myxedema and Ankyloglossia With Or Without Tooth Anomalies. Among its related pathways are Signaling by WNT and ncRNAs involved in Wnt signaling in hepatocellular carcinoma.

2024年12月25日 · Complete information for lnc-LGR5-1 gene (RNA Gene), , including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

2024年12月25日 · LGR4 (Leucine Rich Repeat Containing G Protein-Coupled Receptor 4) is a Protein Coding gene. Diseases associated with LGR4 include Delayed Puberty, Self-Limited and Bone Mineral Density Quantitative Trait Locus 17. Among its related pathways are Signaling by WNT and ncRNAs involved in Wnt signaling in hepatocellular carcinoma.

2024年12月25日 · Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.

2024年12月25日 · The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain.

2024年12月24日 · ENSG00000257761 (Novel Transcript, Antisense To LGR5) is an RNA Gene, and is affiliated with the lncRNA class.

2024年12月25日 · TSPAN8 (Tetraspanin 8) is a Protein Coding gene. Diseases associated with TSPAN8 include Pancreas, Annular and Diabetes Mellitus. Among its related pathways are Extracellular vesicle-mediated signaling in recipient cells and Pancreatic cancer subtypes. An important paralog of this gene is CD81.

2024年12月25日 · Pro-apoptotic protein involved in LGR5-positive intestinal stem cell and Paneth cell expansion in the intestines, via its interaction with XIAP (By similarity). May also play a role in the regulation of cell fate in the intestine (By similarity).