2010年3月12日 · Skin wounds in adult mice are repaired by Lgr6 stem cells in the hair follicles that flank the damage. After hair morphogenesis, Lgr6 stem cells give rise to epidermal and sebaceous gland lineages to generate fully differentiated new skin.

2015年11月10日 · In this article, Kasper and colleagues demonstrate that the hair follicle isthmus, sebaceous gland, and interfollicular epidermis harbor independent self-renewing Lgr6+ progenitor populations and that renewal of these populations follows from neutral competition.

2013年9月25日 · LGR6 + hair follicle cells predominantly contribute to the maintenance of the junctional zone and sebaceous glands 71, although they show some sporadic contribution to the entire hair follicle...

2018年10月16日 · Here, we genetically labeled Lgr5- or Lgr6-expressing cells from the hair follicle bulge and interfollicular epidermis (IFE), respectively, and monitored their individual transcriptional adaptations during wound healing using single-cell transcriptomics.

Postnatally, Lgr6+ cells generated sebaceous gland and interfollicular epidermis, whereas contribution to hair lineages gradually diminished with age. Adult Lgr6+ cells executed long-term wound repair, including the formation of new hair follicles. We conclude that Lgr6 marks the most primitive epidermal stem cell. I

2015年11月10日 · The dynamics and interactions between stem cell pools in the hair follicle (HF), sebaceous gland (SG), and interfollicular epidermis (IFE) of murine skin are still poorly understood. In this study, we used multicolor lineage tracing to mark Lgr6⁺ -expressing basal cells in the HF isthmus, SG, and IF …

2018年10月16日 · Here, we genetically labeled Lgr5- or Lgr6-expressing cells from the hair follicle bulge and interfollicular epidermis (IFE), respectively, and monitored their individual transcriptional adaptations during wound healing using single-cell transcriptomics. Both Lgr5 and Lgr6 progeny rapidly induced a genetic wound signature that, for Lgr5 progeny ...

2010年3月12日 · Mammalian epidermis consists of three self-renewing compartments: the hair follicle, the sebaceous gland, and the interfollicular epidermis. We generated knock-in alleles of murine Lgr6, a close relative of the Lgr5 stem cell gene. Lgr6 was expressed in the earliest embryonic hair placodes.

2021年9月6日 · Thus, our study demonstrated that LGR6 activated a novel β-catenin/TCF7L2/LGR6-positive feedback loop in LGR6 high cervical cancer stem cells (CSCs), which provided a new therapeutic strategy...

2011年10月17日 · Here, we review the discovery and application of Lgr5 and Lgr6 as markers to study adult stem cell roles in epithelial renewal and cancer in the hair-follicle, gastrointestinal tract and skin....