2010年3月12日 · Lgr6 is thus one of the earliest placode markers, resembling Sonic Hedgehog (24) and Sox9 (25). Lgr6 expression persisted during hair peg development (Fig. 1C and fig. S2C). The resulting hair breaks through the overlying epidermis postnatally.

2020年5月8日 · Lgr6 is a marker for distinct stem cells and is able to give rise to all lineages of the skin (HF, sebaceous gland and interfollicular epidermis) [21]. Sox9 is a transcription factor expressed in the sebaceous and sweat glands and the …

2020年5月8日 · In order to understand the presence and potential contribution of stem cells (SCs) as tumour-initiating cells in canine cutaneous tumours, we selected three putative SC markers (Lgr5, Lgr6 and Sox9) and investigated their expression pattern, level of protein and mRNA expression, in 43 canine hair follicle (HF) and 18 canine cutaneous epidermal ...

2024年6月11日 · Lgr6的表达在肿瘤细胞中增加，反映了肿瘤从正常稳态向恶性发展过程中的功能转换。 Lgr5在毛囊下凸起区域高表达，反映了其已知的毛囊干细胞功能，且Lgr5在癌变的所有阶段均低表达。

Lgr6+ stem cells from tumors generated progeny that expressed lineage plasticity markers Sox2, Pitx1, Foxa1, and Cd44, as well as genes associated with quiescence and tumor suppression. This cell state was strongly anticorrelated with an alternative state expressing markers of cell proliferation and DNA damage responses.

Using a multimodal approach for a head-to-head comparison of injury-induced SOX9 lineages, we identified a dynamic SOX9 switch in repairing epithelia. Lineages that regenerated epithelia silenced SOX9 and healed without fibrosis (SOX9 on-off).

In the human lung, LGR6 positive (LGR6 +) cells are a subpopulation located in the bronchioalveolar compartment. In vitro, LGR6 + cells showed ability to self-renewal, with unlimited expansion, and the expression of SCs markers (SOX9, LGR5-6, ITGA6).

In order to understand the presence and potential contribution of stem cells (SCs) as tumour-initiating cells in canine cutaneous tumours, we selected three putative SC markers (Lgr5, Lgr6 ...

Hair follicle stem cells (HFSCs) arise within the early committed placode epithelium before the physical appearance of the bulge. These Sox9 + HFSCs localize to the suprabasal layer and are the earliest long-term label-retaining stem cells (red). Sox9 appears to …

2024年7月4日 · Lgr6 expression was identified in the upper hair follicle and in the interfollicular epithelium, whereas the Lgr6 NSk metagene network was found in differentiated keratinocytes, consistent with...