2022年2月11日 · Here, a multifunctional Rg3 liposome loading with docetaxel (Rg3-Lp/DTX) was developed, in which Rg3 was proved to intersperse in the phospholipid bilayer and exposed its glycosyl on the liposome surface. Therefore, it exhibited much higher CTC-capturing efficiency via interaction with glucose transporter 1 (Glut1) overexpressed on CTCs.

2020年1月10日 · In rat ischemia-reperfusion model, an intramyocardial injection of Rg3-loaded PEG-b-PPS nanoparticles improved the cardiac function and reduced the infarct size. The mechanism of action was established as Rg3 targeting of FoxO3a, which inhibited the promotion of oxidative stress, inflammation, and fibrosis via downstream signaling pathways.

2023年9月1日 · In this work, a ginsenoside Rg3 (Rg3)-functionalized biomimetic nanoplatform is fabricated by encapsulating arsenic trioxide (ATO) and chlorin e6 (Ce6) into exosomes, denoted as Rg3-Exo/ATO@Ce6, to ameliorate photoimmunotherapy via reprogramming the tumor microenvironment (TME).

2023年12月1日 · Herein, ginsenoside Rg3 was selected to substitute cholesterol and PEG for liposomes preparation (Rg3-lipo). Rg3 was proved with similar liposomal membrane regulation ability to cholesterol and comparable long circulation effect to PEG. In addition, repeated administrations of Chol-PEG-lipo and Rg3-lipo were performed.

2020年6月12日 · The current study aimed to unravel the inhibitory effects of Ginsenoside Rg3 (G-Rg3) on inflammation-mediated hepatic autophagy to curb hepatic fibrosis caused by thioacetamide (TAA)-induced...

Herein, ginsenoside Rg3 was selected to substitute cholesterol and PEG for liposomes preparation (Rg3-lipo). Rg3 was proved with similar liposomal membrane regulation ability to cholesterol and comparable long circulation effect to PEG. In addition, repeated administrations of Chol-PEG-lipo and Rg3-lipo were performed.

2022年12月26日 · In this study, we showed that Rg3 protected mice from TAC-Induced cardiac hypertrophy and regulated pyruvate metabolism. We also found that 2-hydroxyisobutyrylation is an essential PTM that...

2020年1月10日 · We identified FoxO3a as the therapeutic target of Rg3 using molecular docking and gene silencing. In rat ischemia-reperfusion model, an intramyocardial injection of Rg3-loaded PEG-b-PPS nanoparticles improved the cardiac function and reduced the infarct size.

Ginsenoside Rg3 (Rg3), was powerful free radical scavengers and possessed cardioprotective effects. Nevertheless, Rg3 has low aqueous solubility and oral bioavailability, limiting its effects. Herein, we encapsulated Rg3 through spontaneous self-assembly of Pluronic F127 to improve its solubility and oral bioavailability.

Ginsenoside Rg3 (Rg3), the main active ingredient of ginseng, has a range of pharmacological effects, including antioxidant, anti-inflammatory, and anti-aging activities [10–13]. Our previous studies confirmed that Rg3-loaded Pluronic F127 micelles alleviated doxorubicin-induced oxidative stress by reversing mitochondrial dysfunction [ 14 ].