
Two-component system GrpP/GrpQ promotes pathogenicity of
2025年1月11日 · Uropathogenic Escherichia coli (UPEC) is a major cause of urinary tract infections (UTIs). Invasion into bladder epithelial cells (BECs) on the bladder luminal surface via...
UroPathogenic Escherichia coli (UPEC) Infections: Virulence …
This review will focus on the most relevant components of UPEC arsenal of pathogenicity together with the major host responses to infection, the current approved treatment and the emergence of resistant UPEC strains, the vaccine strategies, the natural antimicrobial compounds along with innovative anti-adhesive and prophylactic approaches to ...
Uropathogenic Escherichia coli Subverts Host Autophagic …
2024年9月23日 · UPEC infects bladder epithelial cells (BECs) via fusiform vesicles and escapes into the cytosol by disrupting fusiform vesicle membrane using outer membrane phospholipase PldA, and establishes biofilm-like intracellular bacterial communities (IBCs) for protection from host immune clearance.
Mechanisms of uropathogenic E. coli mucosal association in the
2025年1月31日 · UPEC isolates carry an arsenal of proteinaceous, adhesive fibers, called chaperone usher pathway (CUP) pili, each of which is tipped with an adhesin thought to confer binding specificity to host glycans .
我院团队在尿路致病性大肠杆菌致病机制领域取得进展
2025年2月28日 · 团队首次发现了UPEC特异的双组份系统GrpP/GrpQ直接调控细菌特异毒力基因促进其致病性的分子机制。 研究发现,UPEC通过响应尿液中的D-serine作为信号分子,激活其特异的双组份系统GrpP/GrpQ。 磷酸化的GrpQ直接结合1型菌毛的启动子fimS促进其相变从而上调1型菌毛编码基因的表达。...
Uropathogenic Escherichia coli (UPEC)-Associated Urinary Tract ...
Uropathogenic Escherichia coli (UPEC) are the most common cause and accounts for the majority of community-acquired UTIs. Infection by UPEC can cause discomfort, polyuria, and fever. More serious clinical consequences can result in urosepsis, kidney damage, and death.
<br>尿路致病性大肠杆菌 (UPEC) 感染:毒力因素、膀胱反应、抗 …
在与尿路感染发展相关的常见尿路病原体中,尿路致病性大肠杆菌 (UPEC) 是主要原因。 UPEC菌株具有大量的结构性毒力因子(如菌毛、菌毛、卷毛、鞭毛)和分泌性毒力因子(毒素、铁获取系统),这些毒力因子有助于其引起疾病的能力,尽管其能够粘附在宿主上皮细胞上泌尿道是致病性最重要的决定因素。 另一方面,膀胱上皮显示出多方面的宿主防御,包括尿液流动和抗菌物质的分泌,这是对抗细菌感染的有用工具。 这些玩家之间令人着迷且错综复杂的动态决定了一个需 …
Virulence factors of uropathogenic Escherichia coli (UPEC) and ...
Escherichia coli has found to be the predominant uropathogen (50–90%) in uncomplicated, community acquired urinary tract infection (UTI). Uropathogenic Escherichia coli (UPEC) express a multitude of virulence factors, which enable the bacteria to establish UTI.
动物来源的潜在尿路致病性大肠杆菌 (UPEC) 和人类尿路感染 (UTI)
这些分离株是根据其尿路致病性 (UPEC) 状态和系统发育背景进行选择的。 计算机模拟 分析显示相似的毒力基因谱,其中鞭毛、1 型和卷曲菌毛、外膜蛋白(agn43 、 ompT 、 iha)和铁摄取(iutA 、 entA 和 fyuA)相关特征是最普遍的(> 65%)。 在膀胱细胞检测中,uUTI、cUTI 和动物源性分离株分别表现出中度至强关联值(83%、60%、77.8%)和侵袭值(0%、70%、55.5%)。 有趣的是,uUTI 分离株表现出比 cUTI 分离株显着更低的侵袭能力 ( p < 0.05)。 …
Uropathogenic Escherichia coli (UPEC)-Associated Urinary Tract
2023年8月28日 · Uropathogenic Escherichia coli (UPEC) are the most common cause and accounts for the majority of community-acquired UTIs. Infection by UPEC can cause discomfort, polyuria, and fever. More serious clinical consequences can result in …