The LIN-12/Notch signaling pathway and its regulation - PubMed
Notch, LIN-12, and GLP-1 are receptors that mediate a broad range of cell interactions during Drosophila and nematode development. Signaling by these receptors relies on a conserved …
华中科技大学课题组在38分的STTT发表超重磅综述，带你详解这一 …
2023年3月26日 · Notch 信号是造血、免疫细胞分化的关键调节因子之一，与多种自身免疫性疾病、肿瘤的发生和肿瘤诱导的免疫抑制有关。 Notch 信号通路本身简单，但它所调控的细胞进程 …
lin-12, a nematode homeotic gene, is homologous to a set of …
The lin-12 gene of the nematode Caenorhabditis elegans controls certain binary decisions during development. The lin-12 locus was cloned by means of Tc 1 transposon tagging: spontaneous …
LIN-12/Notch Activation Leads to MicroRNA-Mediated Down
2005年11月25日 · Here, we identify a microRNA gene, mir-61, as a direct transcriptional target of LIN-12 and show that expression of mir-61 promotes the 2° fate. We also identify vav-1, the …
LIN-12/Notch Signaling: Induction, Lateral Specification, and ...
2010年1月1日 · LIN-12/Notch receptors are evolutionary conserved type I transmembrane proteins involved in many developmental events. Genetic and biochemical experiments from …
Structure/function studies of lin-12/Notch proteins - PubMed
The lin-12/Notch proteins appear to act as transmembrane receptors for intercellular signals that specify cell fates during animal development. Recent structure/function studies have shown …
Endocytosis-mediated downregulation of LIN-12/Notch upon …
2002年12月12日 · Here we identify a ‘downregulation targeting signal’ (DTS) in the LIN-12 intracellular domain, which encompasses a di-leucine-containing endocytic sorting motif. The …
The lin-12 locus specifies cell fates in caenorhabditis elegans
1983年9月1日 · We describe two classes of mutations in the lin-12 locus of the nematode Caenorhabditis elegans. Ten semidominant mutations (lin-12 [d]) appear to elevate the level of …
Notch/LIN-12 signaling: transduction by regulated protein slicing
1998年9月1日 · Here, we review models for two key steps in Notch/LIN-12 signaling: ligand-mediated activation of the receptor and receptor-mediated activation of transcription. Ligand …
lin-12 and glp-1 are required zygotically for early embryonic …
Cell-cell interactions mediated by LIN-12 and GLP-1, members of the LNG (LIN-12, Notch, GLP-1) family of receptors, are required to specify numerous cell fates during development of the …