Lin-14 - Wikipedia
LIN-14 is a nuclear protein that plays a crucial role in regulating developmental timing in the nematode worm Caenorhabditis elegans. [1] [2] It functions as a heterochronic gene, …
曾与诺奖失之交臂、人小鬼大的miRNA如何改变细胞命运？
秀丽隐感线虫中lin-4调控lin-14的表达 简单来说，生物体内的RNA可分为两种：一种是可编码的，即参与编码蛋白质——遗传物质DNA转录生成mRNA （mRNA，也就是信使RNA，由DNA …
The Heterochronic Gene lin-14 Controls Axonal Degeneration in C ...
2017年9月19日 · The heterochronic gene lin-14 has previously been implicated in regulating the timing of key developmental events in the nematode C. elegans. Here, we report that LIN-14 is …
The lin-4 microRNA targets the LIN-14 transcription factor to …
2012年6月12日 · In AVM neurons, the transcription factor LIN-14, a target of lin-4 microRNA, stimulated UNC-6-mediated ventral guidance of the AVM axon. LIN-14 promoted attraction of …
Posttranscriptional regulation of the heterochronic gene lin-14 by lin …
1993年12月3日 · Here we demonstrate that a temporal gradient in Lin-14 protein is generated posttranscriptionally by multiple elements in the lin-14 3′UTR that are regulated by the …
Nature | 全面揭开线虫神经系统时间转换图谱 - 知乎
2021年11月11日 · 为了进一步对 lin-14 在神经转录组成熟过程中的作用进行鉴定，作者通过ChIP-seq技术（Chromatin immunoprecipitation followed by sequencing）直接检测了LIN-14在L1 …
The heterochronic LIN-14 protein is a BEN domain ... - ScienceDirect
2023年3月27日 · Our findings shed new light on potential mechanisms of LIN-14 function and suggest that BEN domain-containing proteins may have a conserved role in developmental …
The heterochronic LIN-14 protein is a BEN domain transcription …
2023年3月27日 · Our findings shed new light on potential mechanisms of LIN-14 function and suggest that BEN domain-containing proteins may have a conserved role in developmental …
lin-4对异时基因lin-14的转录后调控介导秀丽隐杆线虫的时间模式 …
lin-14 3'UTR是赋予lin-4介导的转录后时间调控的必要和充分条件。lin-14 3'UTR的功能在秀丽隐杆线虫和Briggsae线虫之间是保守的。保守序列中有七个与lin-4 RNA互补的元件。带有三个这 …
lin-14 regulates the timing of synaptic remodelling in ... - Nature
1998年9月3日 · We show that the heterochronic gene lin-14, which controls the timing of stage-specific cell lineages 4, 5, regulates the timing of DD synaptic output remodelling. In lin-14 loss …