Dec 25, 2024 · LITAF (Lipopolysaccharide Induced TNF Factor) is a Protein Coding gene. Diseases associated with LITAF include Charcot-Marie-Tooth Disease, Demyelinating, Type 1C and Charcot-Marie-Tooth Disease Type 1C .

Lipopolysaccharide-induced tumor necrosis factor-alpha factor is a protein that in humans is encoded by the LITAF gene. [5] [6] [7] It is associated with Charcot–Marie–Tooth disease 1C.

Jan 5, 2024 · The strongest candidate (LITAF) was validated via gene overexpression, KO, and mutation approaches in assays of cell survival. Confocal microscopy and biochemical assays (Western blot, immunoprecipitation) were used to determine the mechanism of action. We generated a LITAF-KO mouse using CRISPR to validate the role of LITAF in primary ...

We identify the endolysosomal protein LITAF as a mediator of cellular resistance to PFT-induced cell death that is active against both bacterial toxins and the endogenous pore, gasdermin D, a terminal effector of pyroptosis.

LITAF, a BCL6 target gene, regulates autophagy in mature B-cell lymphomas. The findings indicate a function of SIMPLE as a regulator of endosomal trafficking and provide evidence linking dysregulated endosomal trafficking to CMT pathogenesis.

脂多糖诱导的肿瘤坏死因子： 脂多糖是单核细胞和巨噬细胞的有效刺激物，可引起肿瘤坏死因子-α (TNF-α) 和其他炎症介质的分泌。该基因编码脂多糖诱导的 TNF-α 因子，它是一种 DNA 结合蛋白，可通过直接结合 TNF-α 基因的启动子区域来介导 TNF-α 的表达。该基因的转录由肿瘤抑制因子 p53 诱导，并与 ...

May 15, 2021 · LITAF, also named as p53-inducible gene 7 (PIG7), was initially identified and characterized in the human macrophage cell line THP-1 after stimulation with LPS (Takashiba et al., 1995, Myokai et al., 1999).

Jan 5, 2024 · We identify the endolysosomal protein LITAF as a mediator of cellular resistance to PFT-induced cell death that is active against both bacterial toxins and the endogenous pore, gasdermin D, a terminal effector of pyroptosis.

Feb 25, 2017 · 就litaf的结构特征和生物学功能的研究进展进行概述。 1litaf的结构特点. litaf在人体中广泛存在,定位于染色体16p13.1~16p12.3, 可编码含228个氨基酸残基的蛋白质分子,具有一个保守的litaf结. 构域;c-端有一个ring结构,在ring中有一个跨膜区,在该跨膜区

脂多糖诱导的肿瘤坏死因子（LPS-induced TNF-α,LITAF）,又称p53诱导基因7或溶酶体/晚期内体小膜内在蛋白。 早期研究认为,p53蛋白的164~170位氨基酸肽段导入到人体单核细胞后可抑制LITAF的表达。