The LKB1–AMPK pathway: metabolism and growth control in
LKB1 encodes a serine–threonine kinase that directly phosphorylates and activates AMPK, a central metabolic sensor. AMPK regulates lipid, cholesterol and glucose metabolism in …
AMPK信号通路（二） - 知乎专栏
LKB1也称为STK11（serine/threonine kinase 11），通过激活AMPK抑制细胞生长和增殖，是一种抑癌因子。 其失活与多种肿瘤相关，特别是肺癌。 虽然叫肝激酶，但其实LKB1在人体各组织 …
LKB1-AMPK-mTOR信号传导通路在肿瘤中的研究进展 - PMC
2011年8月9日 · 研究 显示LKB1通过磷酸化磷酸腺苷激活的蛋白激酶(AMP-activated protein kinase, AMPK)，从而激活AMPK，实现对mTOR活性的负向调控。本文就LKB1-AMPK-mTOR …
The LKB1-AMPK pathway: metabolism and growth control in …
LKB1 encodes a serine-threonine kinase that directly phosphorylates and activates AMPK, a central metabolic sensor. AMPK regulates lipid, cholesterol and glucose metabolism in …
The role of LKB1 and AMPK in cellular responses to
2011年4月6日 · Studies from LKB1 and AMPK knockout mice, and the discovery of human disease-causing mutations in AMPK, have pointed to an important role for these signaling …
LKB1 and AMPK and the cancer-metabolism link - ten years after
2013年4月15日 · AMPK is activated >100-fold on conversion from a dephosphorylated form (AMPK) to a form phosphorylated at Thr172 (AMPK-P) catalyzed by at least two upstream …
LKB1 is a master kinase that activates 13 kinases of the AMPK …
2004年2月19日 · Our results show that LKB1 functions as a master upstream protein kinase, regulating AMPK‐related kinases as well as AMPK. Between them, these kinases may …
The LKB1-AMPK pathway: metabolism and growth control in …
In the past decade, studies of the human tumor suppressor LKB1 have uncovered a novel signaling pathway that links cell metabolism to growth control and cell polarity. LKB1 encodes …
LKB1-AMPK axis revisited | Cell Research - Nature
2012年7月17日 · In this study, the authors utilized the A549 lung cancer cell line, which exhibits homozygous inactivating mutations of endogenous LKB1, as a model to study LKB1-AMPK …
LKB1-AMPK-mTOR信号通路在子宫内膜癌的研究现状 - 中华妇幼 …
lkb1是ampk上游重要的激活点，lkb1可正向调控ampk。 LKB1作为一个重要的STK，可以激活AMPK及其下游激酶，如dTORC、ACC、FOXO、raptor、Atg1、CREB、Sqh、SREBP …