2024年12月24日 · CHD8 (Chromodomain Helicase DNA Binding Protein 8) is a Protein Coding gene. Diseases associated with CHD8 include Intellectual Developmental Disorder With …

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Chromodomain-helicase-DNA-binding protein 8 is an enzyme that in humans is encoded by the CHD8 gene. [5][6] The gene CHD8 encodes the protein chromodomain helicase DNA binding …

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2022年10月27日 · CHD8 -related neurodevelopmental disorder with overgrowth (CHD8 -NDD) is characterized by generalized overgrowth, developmental delay / intellectual disability (DD/ID), …

CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors.

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2023年3月7日 · Mutations in the gene encoding chromodomain helicase DNA-binding protein 8 (CHD8) lead to autism symptoms and macrocephaly by a haploinsufficiency mechanism. …

By generating a conditional loss-of-function and an endogenously tagged allele in human pluripotent stem cells, we investigated the molecular function and the interaction of CHD8 with …