Lamin B Receptor: Interplay between Structure, Function and ...
2017年8月31日 · Lamin B receptor (LBR) is an integral protein of the inner nuclear membrane, containing a hydrophilic N-terminal end protruding into the nucleoplasm, eight hydrophobic …
Nuclear envelope protein lamin B receptor protects the genome …
2023年2月19日 · Lamin B Receptor (LBR) is an inner nuclear membrane protein that assembles the nuclear envelope post mitosis. Here we show that LBR depletion induces mitotic defects …
核纤层蛋白B1的功能及其在神经系统疾病和肿瘤中的研究新进展
摘要：核纤层蛋白B1 (Lamin B1)是核纤层蛋白家族重要成员之一，其主要功能在于维持细胞核骨架完整性，并通过影响染色体分布、基因表达及DNA损伤修复等参与细胞的增殖和衰老。 其表 …
Mechanism and role of nuclear laminin B1 in cell senescence and ...
2024年6月1日 · Recent findings show that LMNB1 protein dysfunction interferes with the cellular senescence process, which is highly associated with tumor progression. LMNB1 expression …
Lamin B1和Lamin B受体下调在衰老中的后果。,Cells - X-MOL
One of these proteins is the lamin B receptor (LBR) that binds lamin B1 and tethers heterochromatin to the INM in embryonic and undifferentiated cells. It is replaced by lamin A/C …
Lamin B receptor: Multi-tasking at the nuclear envelope - PMC
Lamin B receptor (LBR) is an integral membrane protein of the interphase nuclear envelope (NE). The N-terminal end resides in the nucleoplasm, binding to lamin B and heterochromatin, with …
The wide and growing range of lamin B-related diseases: from ...
2022年2月8日 · Another spectrum of pathologies connected to lamin B alterations involve mutations in the lamin B receptor (LBR). The LBR is an inner nuclear membrane protein that …
Semi-quantitative RT-PCR amplification of LMNA, LMNB1
In this study, we analysed the functional effects of dysregulated nuclear lamin B1 (LMNB1) and its nuclear receptor (LBR). According to their cellular localisation and function, we revealed that...
Abstract P6-04-14: mRNA expressions of lamin B1 and lamin B …
2013年12月15日 · BACKGROUND: Lamin B (LMNB) and lamin B receptor (LBR) are key components of the nuclear envelope, with roles in chromosomal stability, DNA repair, and cell …
Mapping the micro-proteome of the nuclear lamina and lamina …
In addition to H3K27me3 and H3K9me2/3, A-type lamins and the inner nuclear membrane (INM) proteins lamina-associated polypeptide β (LAP2β) and Lamin B receptor (LBR) have been …