Log P is positive for lipophilic and negative for hydrophilic substances or species. The P-value only correctly refers to the concentration ratio of a single substance distributed between the octanol and water phases.

The ratio is essentially independent of concentration, and is usually expressed in logarithmic terms (log KOW or log Poct), which are better suited for use as a free-energy based parameter in thermodynamic equations.

2004年11月14日 · The octanol/water partition coefficient (Kow) is defined as the ratio of a chemical's concentration in the octanol phase to its concentration in the aqueous phase of a two-phase octanol/water system. Kow = Concentration in octanol phase / …

2024年6月30日 · Relationships between aquatic toxicity, chemical hydrophobicity, and mode of action: log Kow revisited. ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY. Springer, New York, NY, USA, 83 (4): 326-338, (2022). Public: This dataset is intended for public access and use. License: See this page for license information.

2016年1月13日 · Values of Kow are unitless and usually expressed as logKow, a relative indicator of the tendency of an organic compound to adsorb to soil and living organism. LogKow are generally inversely related to water solubility and directly proportional to molecular weight of a …

The LOGKow is the equilibrium ratio of solute concentrations in two immiscible solvents; it describes how much of a given solute dissolves in octanol versus the amount which dissolves in water. This ratio is closely related to a chemical's ability to be absorbed and transported within a biological system.

2019年1月9日 · The n-octanol/water partition ratio or coefficient (log Kow) and n-octanol/water distribution coefficient (log D) are key parameters in environmental risk assessment of chemicals as they are often used to estimate the environmental fate and bioavailability and thus exposure and toxicity of a compound.

The LOGKOW Database contains over 38,000 experimentally determined octanol/water partition coefficients (log P) for almost 23,000 biologically active compounds. Each record in the Database includes a systematic chemical name, the CAS Registry Number, a SMILES structure notation, the method (s) of measurement and references.

The LogKow is the equilibrium ratio of solute concentrations in octanol and water, two immiscible solvents; it measures how much a given solute dissolves in octanol versus the amount which dissolves in water. This ratio is closely related to a chemical's ability to be absorbed and transported within a biological system.

Relationships between toxicity and chemical hydrophobicity have been known for nearly 100 years in mammals and fish, typically using the log of the octanol:water partition coefficient (Kow).