Two types of membrane bound receptors (ionotropic and metabotropic) are activated with the binding of neurotransmitters. Ionotropic receptors such as nicotinic acetylcholine are a group of transmembrane ion channels that open or close in response to …

受体主要由两种：配体门控离子通道(Ligand-gated ion channels, ionotropic receptors)，以及 G蛋白偶联受体 (GPCR, metabotropic receptors)。前者直接调控门控开关，ms数量级，后者间接调控，100ms到分钟数量级

An ionotropic effect is the effect of a transmitter substance or hormone that activates or deactivates ionotropic receptors (ligand-gated ion channels). The effect can be either positive or negative, specifically a depolarization or a hyperpolarization respectively.

Ligand-gated ion channels (LICs, LGIC), also commonly referred to as ionotropic receptors, are a group of transmembrane ion-channel proteins which open to allow ions such as Na +, K +, Ca 2+, and/or Cl − to pass through the membrane in response to the binding of a chemical messenger (i.e. a ligand), such as a neurotransmitter.

离子通道型受体（ionotropic receptor） [2]，离子通道型受体是一类自身为 离子通道 的 受体。 这种离子通道受体与受电位控制的离子通道不同，它们的开放或关闭直接接受化学配体的控制，这些配体主要为 神经递质。 离子通道受体信号转导的最终作用是导致了 细胞膜 电位改变，即是通过将化学信号转变成为电信号而影响细胞的功能的。 [1] 离子通道型受体是一类自身为离子通道的受体，即配体门通道（ligand-gated channel）。 主要存在于 神经 、肌肉等 可兴奋细胞，其信号 …

Ionotropic receptors are ligand-gated ion channels made up of three, four, or five protein subunits that together form an ion-conducting pore in the center of the receptor. There are four families of ionotropic receptors, which differ in their molecular structure and the ligands that open them.

2012年7月30日 · Ionotropic and metabotropic receptors are both ligand-gated transmembrane proteins. Ionotropic receptors change shape when they are bound by a ligand. This change in shape creates a channel that allows ions to flow through. …

The data on the structure, location and function of ionotropic glutamate receptors is shown. These include NMDA-, AMPA-, kainate and orphan receptor, activation them ensures the formation of an action potential. The ionotropic receptors are present in the CNS and peripheral organs.

Glutamate serves as both the mammalian brain’s primary excitatory neurotransmitter and as a key neuromodulator to control synapse and circuit function over a wide range of spatial and temporal scales. This functional diversity is decoded by two receptor families: ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs).

This text gives an overview of presynaptic ionotropic receptors and briefly summarizes the events involved in transmitter release to finally delineate the most important signaling mechanisms that mediate the effects of presynaptic ionotropic receptor activation.