Lipoxygenases (EC 1.13.11.-) (LOX) are a family of (non- heme) iron -containing enzymes, more specifically oxidative enzymes, most of which catalyze the dioxygenation of polyunsaturated fatty acids in lipids containing a cis,cis-1,4- pentadiene into cell signaling agents that serve diverse roles as autocrine signals that regulate the function ...

Lysyl oxidase (LOX), also known as protein-lysine 6-oxidase, is an enzyme that, in humans, is encoded by the LOX gene. [5][6] It catalyzes the conversion of lysine residues into its aldehyde derivative allysine. [7] Allysine form cross-links in extracellular matrix proteins.

Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. LOX enzymes are expressed in immune, epithelial, and tumor cells that display a variety of physiological functions, including inflammation, skin disorder, and tumorigenesis.

12/15-lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids, particularly omega-6 and −3 fatty acids, to generate a number of bioactive lipid metabolites. A large number of studies have revealed the importance of 12/15-LOX role in oxidative and inflammatory responses.

Cu-dependent lysyl oxidase (LOX) plays a catalytic activity-related, primary role in the assembly of the extracellular matrix (ECM), a dynamic structural and regulatory framework which is essential for cell fate, differentiation and communication during development, tissue maintenance and …

Lysyl oxidases (LOX) are copper-dependent enzymes that oxidize lysyl and hydroxylysyl residues in collagen and elastin, as a first step in the stabilization of these extracellular matrix proteins through the formation of covalent cross-linkages, an essential process for …

2019年9月13日 · The lysyl oxidase family comprises five members in mammals, lysyl oxidase (LOX) and four lysyl oxidase like proteins (LOXL1-4). They are copper amine oxidases with a highly conserved catalytic domain, a lysine tyrosylquinone cofactor, and a conserved copper-binding site. They catalyze the first step …

2022年12月1日 · Lipoxygenases (LOXs) are non-heme iron (or in some cases manganese) dependent enzymes that catalyze the regioselective dioxygenation of 1 Z,4 Z -pentadiene moieties of polyunsaturated fatty acids (PUFAs) to produce hydroperoxy fatty acids.

2020年11月1日 · Blockade of Golgi-localized copper transporter ATP7A-mediated copper delivery to LOX family enzymes was demonstrated to significantly reduce tumor growth and cancer metastasis via inhibiting LOX activity [138].

4 天之前 · The lysyl oxidase (LOX) family, which includes the founding member LOX and four LOX-like enzymes (LOXL1 − 4), was originally identified as a secreted enzyme capable of catalyzing the oxidation ...