2020年11月12日 · Lox-1 (lectin-like oxLDL [oxidized low-density lipoprotein] receptor 1) is a transmembrane protein expressed in endothelial cells, platelets, macrophages, smooth muscle …

Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) also known as lectin-type oxidized LDL receptor 1 (LOX-1) is a protein that in humans is encoded by the OLR1 gene. [5] [6] LOX …

The LOX-1 gene has a NF-κB binding site at its 5’ flanking region, and therefore ox-LDL increases the expression of LOX-1 through NF-κB, leading to a vicious cycle of proinflammatory signaling .

OxLDL激活LOX-1会引起内皮细胞改变，其特征是通过增加活性氧来激活核因子-κB，随后诱导粘附分子和内皮细胞凋亡。 在体外，LOX-1的表达是由许多炎性细胞因子，氧化应激，血液动力 …

2021年10月5日 · Here, we clarified the exact role of autophagy modulated by the scavenger receptor lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in esophageal cancer …

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is known as a major receptor for oxidized low-density lipoproteins (oxLDL) and plays a significant role in the genesis of …

The splicing variant LOX IN dimerizes with the native form of LOX-1 and protects cells from damage by oxidized LDL. In the developing field of regenerating medicine, LOX-1 is a …

2015年11月18日 · We used structure-based drug design (SBDD) techniques for finding inhibitors of LOX-1 that block the hydrophobic tunnel and prevent ox-LDL/LOX-1 interactions. Towards …

2004年5月1日 · Lectin-like oxidized LDL receptor-1 (LOX-1) was initially identified as the major receptor for oxidized LDL in endothelial cells. In vitro, LOX-1 expression is induced by many …

2020年11月7日 · In this review, we highlight the latest scientific findings related to LOX-1, its ligands, and their roles in the broad spectrum of CVDs. We describe recent findings from basic …