This study suggested the possible application of FAPI radioligand therapy in FAP-expressing pancreatic cancer. Further evaluation is necessary to find the best radionuclide with shorter half-life, as well as the combination with therapies targeting tumour cells directly.

2023年11月7日 · The findings suggest that [¹⁷⁷Lu]Lu-DOTAGA.FAPi dimer therapy is well-tolerated, safe, and effective for treating end-stage metastatic breast cancer patients. [¹⁷⁷Lu]Lu-DOTAGA.FAPi dimer treatment demonstrated promising efficacy in patients with advanced breast cancer, as indic …

2022年8月1日 · 文中，作者比较了β衰变核素 177 lu和α衰变核素 225 ac分别标记的fapi-46在胰腺癌模型中的治疗效果。研究结果显示，[ 177 lu]fapi-46和[ 225 ac]fapi-46均可抑制肿瘤生长；二者相比，[ 177 lu]fapi-46的治疗效果相对较慢，但持续时间较长。

2023年11月7日 · Between November 2020 and March 2023, a compassionate treatment approach was utilized to administer [177 Lu]Lu-DOTAGA.FAPi dimer radionuclide therapy to heavily pretreated patients with advanced breast cancer. Nineteen patients (18 females, 1 male) with metastatic breast cancer participated in the study, with an average age of 44.6 ± 10.7 years.

2021年9月18日 · Fibroblast activation protein (FAP), which has high expression in cancer-associated fibroblasts of epithelial cancers, can be used as a theranostic target. Our previous study used 64 Cu and 225 Ac-labelled FAP inhibitors (FAPI-04) for a FAP-expressing pancreatic cancer xenograft imaging and therapy.

2024年7月27日 · [177Lu]Lu-FAPI-2286 PTRT, utilized for diverse cancer types, exhibited favorable tolerability in sarcoma patients, with minimal side effects, long-lasting retention of the radiopeptide within the tumor, and promising therapeutic effects. Preliminary findings of this prospective study need to be confirmed through further clinical trials.

2024年11月12日 · [177lu]lu-fapi-xt注射液是一种靶向fap的放射性体内治疗药物，通过将放射性核素镥-177靶向运送至fap阳性表达的实体瘤实现肿瘤的精准治疗。 研究药物： [177Lu]Lu-FAPI-XT注射液

2025年1月11日 · Our study robustly advocates for use of FAP-targeting radiopharmaceuticals, particularly 177 Lu-DOTA-2P(FAPI) 2 , alongside immunotherapy in treating FAP-positive tumors. This combination therapy transforms the TME and enables a translatable approach to increasing the sensitivity …

2023年10月11日 · 该项研究首次评价了177Lu标记经伊文氏蓝（EB）修饰的长半衰期成纤维细胞激活蛋白配体EB-FAPI（177Lu-LNC1004）在手术无法切除且经酪氨酸激酶抑制剂（TKI）治疗后仍进展的转移性碘难治性甲状腺癌患者中的应用，其主要研究目的为探索177Lu-LNC1004的剂量学、安全性及初步疗效。 厦门大学附属第一医院核医学科&闽南PET中心 付浩 、 黄劲雄 及新加坡国立大学 赵天智 博士为该论文的共同第一作者；厦门大学附属第一医院核医学科&闽南PET中心 …

2024年12月22日 · Fibroblast activation protein (FAP), which is overexpressed in cancer-associated fibroblasts (CAFs), represents a promising target for cancer diagnosis and therapy. Hypoxia is a common feature of solid tumors.