2020年8月7日 · 评分与LUAD患者的临床病理分期相关，免疫核心和StromalScore共享的DEGs主要表现为免疫相关基因的富集，PPI网络与单变量COX回归的交集分析，BTK表达与LUAD患者生存及TNM分期的相关性研究

2023年6月1日 · By screening the core genes in lung adenocarcinoma (LUAD) with bioinformatics, our study evaluated its prognosis value and role in infiltration process of immune cells. Using GEO database, we screened 5 gene chips, including GSE11072, GSE32863, GSE43458, GSE115002, and GSE116959.

Accumulating evidence has demonstrated that gene alterations play a crucial role in LUAD development, progression, and prognosis. The present study aimed to identify the hub genes associated with LUAD. In the present study, we used TCGA database to screen the hub genes. Then, we validated the results by GEO datasets.

2024年6月30日 · Exploring differentially expressed genes associated with immune-amino acid metabolism in LUAD could enhance early-stage prediction, facilitate the evaluation of LUAD patient conditions, and aid in determining their prognosis, thus offering valuable insights for subsequent research and clinical practice.

2021年4月16日 · Lung adenocarcinoma (LUAD) is the most common pathological type of lung cancer. At present, most patients with LUAD are diagnosed at an advanced stage, and the prognosis of advanced LUAD is poor. Hence, we aimed to identify novel biomarkers for the diagnosis and treatment of early stage LUAD and to explore their predictive value.

2024年4月4日 · Our study applied these methods to assess causality between plasma proteins and LUAD. Furthermore, we employed a two-step MR to quantify the proportion of risk factors mediated by proteins on LUAD. Finally, protein–protein interaction (PPI) analysis elucidated potential links between proteins and current LUAD medications.

2020年6月16日 · In LUAD, the PPI network contained 233 genes, of which 35 were immune-related genes, and one module with score > 10 was identified from the PPI network (Figure (Figure8A-B). 8 A-B). The module contained one immune-related gene (GAL), one upregulated gene (GNG4), and 17 downregulated genes.

2021年4月16日 · A PPI network consisting of 300 nodes and 1140 edges was constructed, and a significant module including 15 genes was identified. Elevated expression of ASPM, CCNB2, CDCA5, PRC1, KIAA0101, and UBE2T was associated with poor OS in LUAD patients. In the protein level, the hub gene was overexpressed in LUAD patients.

Results: The expression of PPIA in LUAD tissues was significantly upregulated than those in adjacent normal tissues. High PPIA mRNA expression was associated with lymph node metastases and high TNM stage.

2024年6月28日 · Immunohistochemical staining results showed that FKBP3 was highly located in cytoplasm and membrane of cells in LUAD tissues. PPI network analysis results showed that HDAC1, YY1, HDAC2, MTOR, PSMA3, PIN1, NCL, C14orf166, PIN4, and LARP6 were the …