
p38 MAPK signaling in M1 macrophages results in selective …
M2 macrophages promote tumor progression and therapy resistance, whereas proimmunogenic M1 macrophages can contribute to the efficacy of cytostatic and immunotherapeutic …
巨噬细胞M1-M2极化的信号通路研究进展-阮静瑶.pdf
m1 促炎能力过强会增强炎症 至核内, 作为转录因子的调控基因表达。 jak/stat 反应并促进一些炎症性疾病的进展, 如动脉粥样硬 信号通路与由各种细胞因子诱导的各种生物学应答 化、重症 …
M1 巨噬细胞中的 p38 MAPK 信号通过 MEK 抑制选择性消除 M2
进一步的分析表明,仅在 M1 巨噬细胞中激活的 p38 MAPK 通路使这些细胞对 MEK 抑制的死亡具有抗性。 总之,M2 巨噬细胞对 MEK/细胞外信号调节激酶 (ERK) 通路的依赖性使 MEK 抑制 …
Cell Reports丨巨噬细胞极化机制的全局特征和 M2 型极化抑制剂的 …
2023年9月22日 · 作者发现,mek 抑制剂能有效阻止 m2 型巨噬细胞的极化,而不是 m1 型巨噬细胞的极化,它们甚至能诱导一些关键的 m1 型标记物的表达(图 3c 和 3f)。 在多种 HDAC …
Advanced glycation end products enhance M1 macrophage polarization …
2020年4月30日 · We examined cytokine secretion, M1 and M2 macrophage-associated marker expression and MAPK phosphorylation levels in AGEs-stimulated macrophages. MIN6 cells …
p38 MAPK signaling in M1 macrophages results in selective …
We found that activation of the p38 MAPK pathway in M1 macrophages makes these cells independent of the MEK/ERK pathway and thereby rescues them from death by MEK …
GDF11 Regulates M1 and M2 Polarization of BV2 Microglial
1 天前 · The addition of SB203580 partially reversed the enhanced M1 polarization marker (NOS2) and restored the M2 polarization marker (ARG1) in GDF11-silenced cells (Fig. 8C, F, …
LXRα agonists ameliorates acute rejection after liver …
5 天之前 · In conclusion, LXRα agonists can inhibit inflammation through the ABCA1/MAPK pathway and M1 polarization of macrophages by inhibiting PI3K/AKT/mTOR. Also, LXRα …
Areca nut polysaccharide induces M1 macrophage ... - ScienceDirect
2024年11月1日 · ANP induces the M1 polarization of macrophages by activating the NF-κB and MAPK signaling pathways, releasing NO, TNF-α and IL-6. ANP does not interact with the …
TLR4-MAPK/NF-κB信号通路下调M1巨噬细胞极化 - 行业资讯—干 …
mapk是一组进化保守的丝氨酸 苏氨酸蛋白激酶,可分为4个亚族:细胞外信号调节激酶 、丝裂原活化蛋白激酶38、c6n末端激酶和大丝裂原活化蛋白激酶1(也称erk5)