M2 macrophages promote tumor progression and therapy resistance, whereas proimmunogenic M1 macrophages can contribute to the efficacy of cytostatic and immunotherapeutic strategies. The abundance of M2 macrophages in the immune infiltrate of many cancer types has prompted the search for strategies t …

m1 促炎能力过强会增强炎症 至核内， 作为转录因子的调控基因表达。 jak/stat 反应并促进一些炎症性疾病的进展， 如动脉粥样硬 信号通路与由各种细胞因子诱导的各种生物学应答 化、重症急性胰腺炎等。

进一步的分析表明，仅在 M1 巨噬细胞中激活的 p38 MAPK 通路使这些细胞对 MEK 抑制的死亡具有抗性。 总之，M2 巨噬细胞对 MEK/细胞外信号调节激酶 (ERK) 通路的依赖性使 MEK 抑制剂能够选择性地从肿瘤微环境中消除该亚群。 p38 MAPK signaling in M1 macrophages results in selective elimination of M2 macrophages by MEK inhibition.

2023年9月22日 · 作者发现，mek 抑制剂能有效阻止 m2 型巨噬细胞的极化，而不是 m1 型巨噬细胞的极化，它们甚至能诱导一些关键的 m1 型标记物的表达（图 3c 和 3f）。 在多种 HDAC 抑制剂中也观察到了这种优先抑制 M2- 而非 M1 型极化的选择性（图 3C 和 3D）。

2020年4月30日 · We examined cytokine secretion, M1 and M2 macrophage-associated marker expression and MAPK phosphorylation levels in AGEs-stimulated macrophages. MIN6 cells were cocultured with AGEs-pretreated macrophages to study the effect of AGEs-induced macrophage activation on β-cell dysfunction.

We found that activation of the p38 MAPK pathway in M1 macrophages makes these cells independent of the MEK/ERK pathway and thereby rescues them from death by MEK inhibition, while the survival of M2 macrophages critically depends on the MEK/ERK pathway.

1 天前 · The addition of SB203580 partially reversed the enhanced M1 polarization marker (NOS2) and restored the M2 polarization marker (ARG1) in GDF11-silenced cells (Fig. 8C, F, G), suggesting that p38 MAPK is a critical mediator of the observed effects. These findings further support the idea that GDF11 regulates microglial polarization by modulating ...

5 天之前 · In conclusion, LXRα agonists can inhibit inflammation through the ABCA1/MAPK pathway and M1 polarization of macrophages by inhibiting PI3K/AKT/mTOR. Also, LXRα agonist can significantly reduce AR after LT. The combination of LXRα agonist and tacrolimus can alleviate AR after LT, indicating that LXRα may become an innovative target for AR ...

2024年11月1日 · ANP induces the M1 polarization of macrophages by activating the NF-κB and MAPK signaling pathways, releasing NO, TNF-α and IL-6. ANP does not interact with the TLR2 and TLR4 receptors but directly enters macrophages to exert immunomodulatory effects.

mapk是一组进化保守的丝氨酸 苏氨酸蛋白激酶，可分为4个亚族：细胞外信号调节激酶 、丝裂原活化蛋白激酶38、c6n末端激酶和大丝裂原活化蛋白激酶1（也称erk5）