2019年1月28日 · Many of these CD68 + αSMA + cells also expressed CD206, again suggesting that they had transitioned from an M2 macrophage 28,29. The evidence for MMT in two contrasting models of renal fibrosis ...

2025年1月27日 · The changes in M2 macrophage marker expression align with the alterations in the number of MMT cells, further confirming that M2 macrophages are the primary subsets driving MMT. These findings underscored the critical role of the METTL3/Smad3 axis in mediating M2-driven MMT during CAR-associated fibrosis.

2024年9月9日 · 这些研究不仅深入剖析了巨噬细胞在维持免疫稳态、调控炎症反应（如M1-M2极化平衡）以及影响血管与组织重构等关键生理病理过程中的角色，还不断拓展至新的研究领域，其中巨噬细胞向肌成纤维细胞转化（ MMT, Macrophage-to-Myofibroblast Transition）便是近年来备受 ...

Additionally, the METTL3 inhibitor STM2457 effectively reversed M2-driven MMT and alleviated fibrotic tissue damage in CAR. These findings highlight that METTL3 enhances M2-driven MMT in renal fibrosis during CAR by promoting the TGF-β1/Smad3 axis, suggesting that METTL3 is a promising therapeutic target for mitigating renal fibrosis in CAR.

巨噬细胞是肾脏疾病发病机制的核心，是肾损伤和纤维化的有效治疗靶点。其中，M2型巨噬细胞在抗炎作用和组织修复方面具有双刃作用。根据患病微环境中 M2 亚型（M2a 或 M2c）的极化，它们可以介导正常组织修复或驱动组织纤维化。在肾纤维化中，M2a 通过巨噬细胞向肌成纤维细胞转化 …

2016年12月1日 · We next examined whether MMT cells exhibited an M2 phenotype based on the well-characterized M2 marker, CD206. Three-color confocal microscopy was performed in six cases with active fibrosis.

2024年12月10日 · For example, in renal UUO models, 80 % of MMT cells (F4/80+α–SMA+) express CD206 according to flow cytometry results, indicating a predominance of the M2 phenotype (CD206 positive) [21]. In renal graft rejection, dual-colour immunofluorescence analysis has shown that 75 % of CD68 + macrophages co-express CD206, and up …

2024年11月19日 · In the process of MMT, it is unclear whether epor is involved. In this study, when BMDM was induced by tgf-β1, the number of F4/80 + α-SMA + cells increased, the cells polarized toward M2, and the expression of tgf-β1 increased. After the activation of epor, the number of F4/80 +α-SMA + cells and the polarization level of M2 were further ...

Additionally, the METTL3 inhibitor STM2457 effectively reversed M2‐driven MMT and alleviated fibrotic tissue damage in CAR. These findings highlight that METTL3 enhances M2‐driven MMT in renal fibrosis during CAR by promoting the TGF‐β1/Smad3 axis, suggesting that METTL3 is a promising therapeutic target for mitigating renal fibrosis in ...

Further analysis revealed that the CD206 + M2 macrophages co-expressed α-SMA, FSP-1 and FAP-α, suggesting that MMT cells had a predominant CD206 + M2 phenotype . In studies of other fibrotic disorders, the CD206 + subset of M2 macrophages is strongly associated with fibrosis, and the MMT cells are largely derived from the CD206 + subset of M2 ...