
N6-methyladenosine regulates the stability of RNA:DNA hybrids ... - Nature
2019年12月16日 · Nature Genetics - N6-methyladenosine (m6A) is prevalent at RNA:DNA hybrids in human pluripotent stem cells. The m6A reader YTHDF2 interacts with R-loop …
The role of m6A modification in the biological functions and
2021年2月21日 · N 6 -methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic...
RNA m6A regulates transcription via DNA demethylation and
2022年9月7日 · We show that RNA m 6 A guides DNA 5mC demethylation and thereby reprograms chromatin accessibility and gene transcription. Our results uncover a layer of …
N6-Methyladenosine in RNA and DNA: An Epitranscriptomic and …
The mRNA m6A modification has been characterized biochemically, molecularly, and phenotypically, including elucidation of its methyltransferase complexes (m6A writer), …
学术争鸣 | 从迷雾重重到柳暗花明?全面起底DNA 6mA修饰相关研 …
该研究发现哺乳动物中的6mA修饰主要集中在线粒体DNA上(平均每个mtDNA分子有4个6mA),而核基因组DNA的6mA量极低。同时,研究者鉴定了主要定位在线粒体中 …
RNA m6A甲基化修饰和特定基因m6A位点的检测方法|干货分享
N6-甲基腺苷 (N6-methyladenosine, m6A)是真核生物mRNA中最丰富的化学修饰,在基因表达调控中发挥着重要作用,包括转录调控和转录后调控。 m6A是一种可逆修饰,分别由 甲基转移酶 …
N6-Methyladenosine, DNA Repair, and Genome Stability - Frontiers
2021年4月8日 · DNA damage agents induce strand breaks to activate DNA damage response and ATM, which phosphorylates and activates METTL3. DNA damage response then leads to …
Emerging Roles for DNA 6mA and RNA m6A Methylation in …
2023年9月9日 · Epigenetic methylation has been shown to play an important role in transcriptional regulation and disease pathogenesis. Recent advancements in detection techniques have …
Nat Rev Genet(IF=60)| m6A最新综述!总结m6A参与调节的生 …
N6 -甲基腺嘌呤(N6-Methyladenosine, m6A)是最丰富的转录组修饰之一,在所有生命的细胞RNA中都有发现。 检测和制图方法的进步提高了我们对m6A对mRNA命运和核糖体RNA功能的影响 …
良渚实验室熊旭深团队合作揭示m6A与表观基因组互作及疾病意义 …
2024年7月13日 · 6-甲基腺嘌呤(N6-methyladenosine, m6A)修饰作为信使RNA(mRNA)上含量最丰富且最为普遍的修饰,已被广泛报道参与调控mRNA的成熟加工、降解、出核和翻译等 …
- 某些结果已被删除