The majority of monoclonal antibody (mAb) therapeutics possess the ability to engage innate immune effectors through interactions mediated by their fragment crystallizable (Fc) domain. By delivering Fc-Fc gamma receptor (FcγR) and Fc-C1q interactions, mAb are able to link exquisite specificity to powerful cellular and complement-mediated ...

Optimized FcγR-mediated effector functions regarding clinical safety and efficacy are addressed with modification strategies such as point mutations, altered glycosylation patterns, combination of different Fc subclasses (cross isotypes), and Fc-truncation of the mAb. These strategies opened the field for a next generation of therapeutic mAbs.

抗体的Fc片段能够结合血清补体分子（C1q），继而形成膜攻击复合物（MAC）清除目的细胞。 补体的激活过程是个级联过程。 首先是识别阶段：抗原与抗体结合后，C1q能识别抗体上的补体结合点，并与之结合。

2019年11月18日 · In particular, cancer therapeutic mAbs can recognize cell-surface proteins on target cells and then kill the targeted cells by multiple mechanisms that are dependent upon a fragment crystallizable...

This review article discusses current understanding of PK of therapeutic mAb and Fc-fusion proteins. As a large and polar molecule, mAb and Fc-fusion molecules have PKs that are substantially different from that of small molecule drugs. FcRn mediated recycling is the primary determinant of an IgG antibody’s PK properties.

2010年3月22日 · Molecular engineering has enabled the fine-tuning of monoclonal antibody (mAb) function to enhance their effects and to minimize immunogenicity and side effects. In this article we take a...

2021年8月19日 · Optimized FcγR-mediated effector functions regarding clinical safety and efficacy are addressed with modification strategies such as point mutations, altered glycosylation patterns, combination of different Fc subclasses (cross isotypes), and Fc-truncation of the mAb. These strategies opened the field for a next generation of therapeutic mAbs.

Fc tails of mAbs have furthermore the potential to initiate complement-dependent lysis as well as immune effector cell-mediated tumour cell killing via binding to Fc receptors. Natural killer cells can induce apoptosis via antibody-dependent cellular cytotoxicity (ADCC), whereas macrophages are able to phagocytose mAb-opsonized tumour cells ...

Through Fab or Fc engineering, IgG-FcRn interaction can be used to generate a variety of therapeutic anti-bodies with significantly enhanced half-life or ability to remove unwanted antigen from circulation. Glycosyla-tion of a mAb or Fc-fusion protein can have a significant impact on the PK of these molecules. mAb charge can

mAb主要通过对流作用通过淋巴管吸收，可以通过皮下（sc）途径与透明质酸酶共同配制，以大剂量/大剂量方便地给药。 mAb的人PK值可以使用食蟹猴数据和异速缩放法合理地估算。