
MAF Gene - GeneCards | MAF Protein | MAF Antibody
2024年12月25日 · MAF (MAF BZIP Transcription Factor) is a Protein Coding gene. Diseases associated with MAF include Ayme-Gripp Syndrome and Cataract 21, Multiple Types. Among its related pathways are Gene expression (Transcription) and RUNX2 regulates bone development.
MAF (gene) - Wikipedia
Transcription factor Maf, also known as proto-oncogene c-Maf or V-maf musculoaponeurotic fibrosarcoma oncogene homolog, is a transcription factor that in humans is encoded by the MAF gene. [5][6] One type, MafA, also known as RIPE3b1, [7] promotes pancreatic development, as well as insulin gene transcription. [8]
MAF MAF bZIP transcription factor [Homo sapiens (human)] - Gene …
2025年2月8日 · Transcription Factor c-Maf Promotes Immunoregulation of Programmed Cell Death 1-Expressed CD8 (+) T Cells in Multiple Sclerosis.
MAF Gene: What is it and Why is it Important?
MAF, also known as c-Maf, is a transcription factor that can act as both an activator and repressor of gene expression. It plays a role in lens development, specifically in the differentiation of lens fiber cells. MAF interacts with coactivators CREBBP and …
The role and regulation of Maf proteins in cancer
2023年2月7日 · The traffic-jam, the D. melanogaster ortholog of the large Maf gene, is exclusively expressed in somatic gonadal cells directly adjacent to germline cells. The traffic jam dysfunction leads to improper intermingling of somatic cells with germ cells, resulting in defective differentiation of germ cells.
MAF amplification licenses ERα through epigenetic remodelling to …
2023年11月9日 · We identify metastasis-promoting genes that are de novo licensed following oestrogen exposure in a MAF-dependent manner. The histone demethylase KDM1A is key to the epigenomic remodelling that...
MAF proteins: a family of regulating and regulated molecules
2018年11月16日 · The proteins of MAF family (the cellular counterpart of viral oncogene MAF, isolated from avian musculoaponeurotic fibrosarcoma) are transcription factors regulating gene expression. On the bases of the size, they are sub-grouped into two families: the “large” (L-MAFs: MAFA, MAFB, c-MAF, and Nrl) and the “small” (S-MAFs: MAFF, MAFK, and ...
Small Maf proteins (MafF, MafG, MafK): History, structure and function
2016年7月25日 · The small Maf proteins (sMafs) are basic region leucine zipper (bZIP)-type transcription factors. The basic region of the Maf family is unique among the bZIP factors, and it contributes to the distinct DNA-binding mode of this class of proteins.
MAF人源基因|MAF基因突变_致病性_靶点-RDDC官网
这个基因编码的蛋白质是一个结合DNA的、包含亮氨酸拉链的转录因子,它可以作为同源二聚体或异源二聚体发挥作用。 根据结合位点和结合伙伴的不同,编码的蛋白质可以是转录激活子或抑制子。 这个蛋白质在调节几个细胞过程中发挥重要作用,包括胚胎晶状体纤维细胞发育、T细胞对凋亡的敏感性增加和软骨细胞终末分化。 这个基因的缺陷是导致青少年发作的颗粒性白内障以及先天性蓝绀性白内障4(CCA4)的原因。 已经发现这个基因有两个转录变异体,编码不同的异构体 …
4094 - Gene ResultMAF MAF bZIP transcription factor [ (human)]
Gene ID: 4094, updated on 8-Feb-2025. The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor.