MAP3K1 (or MEKK1) is a serine/threonine kinase and ubiquitin ligase that performs a pivotal role in a network of enzymes integrating cellular receptor responses to a number of mitogenic and …

2024年12月25日 · MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) is a Protein Coding gene. Diseases associated with MAP3K1 include 46,Xy Sex Reversal 6 and 46,Xy …

Full length MAP3K1 regulates cell migration and contributes to pro-survival signaling while its caspase 3-mediated cleavage generates a C-terminal kinase domain that promotes apoptosis. …

The MAP3K1 gene provides instructions for making a protein that helps regulate signaling pathways that control various processes in the body, including the processes of determining …

2018年5月24日 · Our findings suggest that cancers having mutations in MAP3K1 or MAP2K4, which are frequent in tumors of breast, prostate and colon, may respond to MEK inhibitors. …

摘要：MAP3K1是促分裂原活化蛋白激酶的激酶的激酶（MAP3K）家族的一个成员，调节细胞凋亡、生存、迁移、分化等多重作用。 MAP3K1既可以调节蛋白质磷酸化，又参与泛素-蛋白酶系 …

MAP3K1 expression is associated with progression and poor prognosis of hormone receptor-positive, HER2-negative early-stage breast cancer. Exome sequencing identifies breast …

Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase (MAP3K1) is a gene that encodes a protein that functions as a serine/threonine kinase in multiple cell signaling …

2024年10月17日 · MAP3K1, or MEKK1, is a mitogen-activated protein kinase (MAPK) kinase kinase that regulates the ERK (see 601795) and JNK (see 601158) MAPK pathways, as well …

2013年8月22日 · Clinical resource with information about MAP3K1, 46,XY sex reversal 6, A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast …