MAP3K1 (or MEKK1) is a serine/threonine kinase and ubiquitin ligase that performs a pivotal role in a network of enzymes integrating cellular receptor responses to a number of mitogenic and metabolic stimuli, including: TNF receptor superfamily (TNFRs), T-cell receptor (TCR), Epidermal growth factor receptor (EGFR), and TGF beta receptor ...

2024年12月25日 · MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) is a Protein Coding gene. Diseases associated with MAP3K1 include 46,Xy Sex Reversal 6 and 46,Xy Complete Gonadal Dysgenesis. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and TNFR1 Pathway.

Full length MAP3K1 regulates cell migration and contributes to pro-survival signaling while its caspase 3-mediated cleavage generates a C-terminal kinase domain that promotes apoptosis. The critical function of MAP3K1 in cell fate decisions suggests that it may be a target for deregulation in cancer.

The MAP3K1 gene provides instructions for making a protein that helps regulate signaling pathways that control various processes in the body, including the processes of determining sex characteristics before birth. The MAP3K1 protein attaches (binds) to other molecules called RHOA, MAP3K4, FRAT1, and AXIN1.

2018年5月24日 · Our findings suggest that cancers having mutations in MAP3K1 or MAP2K4, which are frequent in tumors of breast, prostate and colon, may respond to MEK inhibitors. Our findings also suggest that...

摘要：MAP3K1是促分裂原活化蛋白激酶的激酶的激酶（MAP3K）家族的一个成员，调节细胞凋亡、生存、迁移、分化等多重作用。 MAP3K1既可以调节蛋白质磷酸化，又参与泛素-蛋白酶系统。 全长MAP3K1调节细胞迁移，在半胱氨酸-天门冬氨酸蛋白酶（Caspase-3）酶切生成的C-端片段包含激酶结构域促进细胞凋亡。 MAP3K1调节细胞命运的重要功能，意味着其可能是控制癌症的靶点。 近期的大量基因组学研究，MAP3K1基因拷贝数异常、染色体突变、基因无效突变，发生 …

MAP3K1 expression is associated with progression and poor prognosis of hormone receptor-positive, HER2-negative early-stage breast cancer. Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk.

Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase (MAP3K1) is a gene that encodes a protein that functions as a serine/threonine kinase in multiple cell signaling cascades.

2024年10月17日 · MAP3K1, or MEKK1, is a mitogen-activated protein kinase (MAPK) kinase kinase that regulates the ERK (see 601795) and JNK (see 601158) MAPK pathways, as well as the transcription factor NF-kappa-B (see 164011) and …

2013年8月22日 · Clinical resource with information about MAP3K1, 46,XY sex reversal 6, A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age., A multistage genome-wide association study in breast cancer identifies two new risk alleles at ...