A fatty acid oxidation-dependent metabolic shift regulates the ...
Increased FAO is required for BRAFV600E -mutant melanoma cells to survive under the MAPKi-induced metabolic stress prior to acquiring drug resistance. The upfront and concomitant …
p38α MAPK antagonizing JNK to control the hepatic fat ... - Nature
2017年10月12日 · In conculsion, our findings demonstrate that hepatic p38α MAPK functions as a negative regulator of liver steatosis in maintaining BA synthesis and FAO by antagonizing the …
Reversing metabolic reprogramming by CPT1 inhibition with …
2025年1月1日 · Inhibition of FAO by CPT1 KO or Etomoxir decreases PARP1 expression, negatively regulates ADP-ribosylation modification of DUSP1 and dephosphorylates p38 …
Nature Immunology丨CD40 信号重新连接脂肪酸和谷氨酰胺代谢 …
Here we show that CD40 activation triggers fatty acid oxidation (FAO) and glutamine metabolism to promote ATP citrate lyase-dependent epigenetic reprogramming of pro-inflammatory genes …
Towards understanding cancer dormancy over strategic hitching …
2025年2月14日 · Dormant cancer cells switch on stress-induced signaling such as the p38 MAPK pathway, PRKR-like endoplasmic reticulum kinase (PERK), and hypoxia-inducible factors …
脂肪酸氧化依赖性代谢转移调节BRAF突变的黑色素瘤对MAPK抑制 …
结果用mapki处理的黑素瘤细胞显示cd36和pparα介导的肉碱棕榈酰转移酶1a（cpt1a）依赖性脂肪酸氧化（fao）水平升高。尽管cd36是适应性和耐药性阶段黑色素瘤细胞的有用标志物， …
Comparative genomics of MAP kinase and calcium–calcineurin …
Mitogen-activated protein kinase (MAPK) cascades and the calcium–calcineurin pathway control fundamental aspects of fungal growth, development and reproduction. Core elements of these …
MAPK pathway‐related tyrosine phosphatases regulate …
In this study, we identified five MAPK pathway‐related phosphatases (Msg5, Yvh1, Ptp1, Ptp2 and Oca2) and characterized their functions in Aspergillus flavus, which produces aflatoxin B₁ …
MAPK级联调控细胞生长及其在免疫、炎症及癌症中作用的研究进展
2023年1月14日 · 丝裂原活化蛋白激酶 (mitogen-activated protein kinase，MAPK)级联系统是真核生物细胞中高度保守的信号系统之一，参与诸多生物学过程的调控。 在细胞因子、神经递质 …
MAPK Cascades and Transcriptional Factors: Regulation of Heavy …
The mitogen-activated protein kinase (MAPK) cascade transfers the signals perceived by cell membrane surface receptors to cells through phosphorylation and dephosphorylation and …