MAP kinase-activated protein kinase 2 is an enzyme that in humans is encoded by the MAPKAPK2 gene. [5][6][7] This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase.

2024年12月25日 · MAPKAPK2 (MAPK Activated Protein Kinase 2) is a Protein Coding gene. Diseases associated with MAPKAPK2 include Monocytic Leukemia and Pheochromocytoma. Among its related pathways are Toll Like Receptor 7/8 …

2023年3月16日 · In this study, using the dynamic network biomarker (DNB) method, we first identified the critical time point when α-Syn undergoes pathological aggregation based on a SH-SY5Y cell model and found...

Learn how p38 MAPK is involved in regulation of HSP27, MAPKAPK-2, MAPKAPK-3, & several transcription factors.

The 30-amino acid docking domain peptide of MAPKAPK2 isoform a (MK2a) is required for the formation of a tight, functional p38alpha-MK2a signaling complex. Kaposin B reverses the instability of cytokine trnscripts by binding to and activating mitogen-activated protein kinase-associated protein kinase 2, a target of the p38 mitogen-activated ...

该激酶通过 p38 MAP 激酶的直接磷酸化进行调节。 与 p38 MAP 激酶结合，已知该激酶参与许多细胞过程，包括应激和炎症反应、核输出、基因表达调节和细胞增殖。 热休克蛋白 HSP27 被证明是该激酶在体内的底物之一。 已发现该基因的两个转录变体编码两种不同的亚型。 [RefSeq 提供，2008 年 7 月] This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase.

2019年3月8日 · Post-transcriptional regulation of genes harboring adenine/uridine-rich elements (AREs) in their 3′-untranslated region (3′-UTR) is controlled by MAPK-activated protein kinase 2 (MAPKAPK2 or MK2), a downstream substrate of the p38MAPK.

2015年8月17日 · Here we report a mechanism by which mTOR controls the SASP by differentially regulating the translation of the MK2 (also known as MAPKAPK2) kinase through 4EBP1. In turn, MAPKAPK2...

作用于内耳发育的上游或内耳发育； p38mapk 级联；和基因表达的正调控。位于细胞质和细胞核中。以多种结构表达，包括中枢神经系统；眼睛;泌尿生殖系统；直觉;和免疫系统。与人 mapkapk2（mapk 活化蛋白激酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

MAP kinase-activated protein kinase 2 is a protein in humans that is encoded by MAPKAPK2 gene. Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation.