2021年12月1日 · We established an MC38 colon cancer cell lung metastasis model for Fas overexpression in male adipocytes (Fas CKI/CKI×Adi-cre) and littermates (Fas CKI/CKI) after a high-fat diet for 6 weeks.

2019年2月1日 · Fas expression level in subsets of colon cancers was compared in murine colon carcinoma CT26, MC32a, and MC38 cell lines and human colon carcinoma HCT116 and SW480 cell lines. CD133 + and CD24 lo were used to define the phenotype of colon CSC-like cells ( …

2021年12月1日 · In this study, we found that the increased tumor necrosis factor-alpha (TNF-α) in adipocytes promoted the lung metastasis of MC38 colon cancer cells via Fas signaling.

2016年4月18日 · Monocytes/macrophages, but not granulocytes, isolated from experimental liver metastases stimulated migration and invasion of MC38 colon and Lewis lung carcinoma cells.

2003年6月15日 · Irradiation induced significant expression of Fas on both MC38 and MC38-CEA + cells in a dose-dependent manner (Fig. 2, A–D). The maximum up-regulation of Fas was noted at 10–20 Gy. MC38 and MC38-CEA + cells subjected to 8 Gy irradiation expressed Fas

2023年1月1日 · They found that cell-surface expression of Fas was upregulated in irradiated than in nonirradiated MC38-CEA+ tumor cells, and peaked at the treatment of 50 and 100 μCi 90 Y-labeled COL-1. Through MC38-CEA-DN1 tumors (Fas nonfunctional) models, they confirmed that increased survival treatment with 90 Y-labeled COL-1 was mediated by engagement ...

2003年6月15日 · Treatment of carcinoembryonic Ag-expressing MC38 adenocarcinoma cells with irradiation (20 Gy) in vitro enhanced Fas expression at molecular, phenotypic, and functional levels. Furthermore, irradiation sensitized these targets …

Here we use the well described murine colon cancer cell line MC38 to address the role of Fas Ag, Fas L and Fas apoptosis resistance in the behavior of colon cancer cells. We demonstrate that Fas Ag mediated proliferative signaling is responsible for local tumor growth.

2020年10月20日 · By comparing MC38-OT I-bearing PPARα −/− mice to their WT littermates, we found that PPARα deficiency resulted in decreased lipid content (Figure 6 D), a higher ratio of antigen-specific tet + CD8 + T cells (Figure 6 E), and improved function of CD8 + …

In this study, we found that the increased tumor necrosis factor-alpha (TNF-α) in adipocytes promoted the lung metastasis of MC38 colon cancer cells via Fas signaling.