In the present study, four CRC cell lines were utilized, comprising three human cell lines (HCT116, SW480 and SW620) and one mice cell line (MC38), alongside two copper ionophores, Elesclomol and Disulfiram, to investigate the impact of cuproptosis on CRC cells.

2023年7月5日 · Intratumoral glutamine supplementation inhibits tumour growth by augmenting cDC1-mediated CD8 + T cell immunity, and overcomes therapeutic resistance to checkpoint blockade and T cell-mediated...

Antitumor activity of Tencentriq and another anti-PDL1 antibody (n=8).

2023年9月21日 · The M1-like and M2-like macrophages were stained with anti-CD86 and anti-CD206 antibodies, respectively. The proportions of tumour cells, M1- and M2-like macrophages among the PGN-positive cells...

2025年2月18日 · In line with the upregulated CD86 on BMDCs (Figure S1 M), BMDCs co-cultured with HTH-01-015-pretreated tumor cells showed strong stimulatory effects on CD8 + OT-1 T cells as indicated by the increased cytotoxic maker CD107a and proliferative marker Ki67 (Figure 1 L). These findings demonstrate the potential of NUAK1 inhibition to efficiently ...

2024年5月29日 · To evaluate the impact of hsBCL9 z96 treatment on antigen-specific CD8 + T cells in vivo, we established a murine model with MC38 tumor cells overexpressing ovalbumin (OVA) (MC38-OVA).

To determine whether the antitumor efficacy of anti–PD-1 can be enhanced when CD28 binds its natural ligand(s), we used the well-established C57BL6 syngeneic MC38 mouse tumor model; MC38 cells were engineered to overexpress murine CD86, one of the costimulatory ligands for CD28 (MC38/CD86, fig. S1A).

2023年7月19日 · Inhibition of MC38 colon cancer growth by multicomponent chemoimmunotherapy with anti-IL-10R antibodies, HES-MTX nanoconjugate, depends on application of IL-12, IL-15 or IL-18 secreting dendritic cell vaccines

我们的研究结果表明，hp-aps对肿瘤细胞增殖具有抑制作用，可诱导肿瘤细胞凋亡，阻止细胞在细胞周期中从g1期向s期转化。此外，hp-aps 可有效增加 hsp70、crt、mhc-i、cd86、cd80 和 atp 释放的表达。t细胞增殖指数明显提高。ot1小鼠cd3细胞增殖从第4代到第5代显着增加。

2021年11月7日 · 结果 随着小鼠结肠癌肿瘤的增长，CD45 + 细胞水平总体表现出下降趋势，CD8 + T细胞水平稳步下降至不可逆的水平，而CD4 + T细胞比例在荷瘤早期迅速增长，单位体积中浸润细胞数增长了近8倍，肿瘤浸润的T细胞几乎为CD4 + 表型。 以NK细胞为代表的非特异性免疫应答水平持续下降，而树突状细胞在肿瘤内持续累积，并通过激活精氨酸酶 1（Arginase-1，ARG1）和诱导型一氧化氮合成酶（inducible nitric oxide synthetase，iNOS），进一步加深免疫抑制作 …