【协和医学杂志】整合素αvβ3靶向放射性药物99mTc-RGD联合抗P…
2023年8月27日 · 本研究发现， 99m Tc-RGD 可显著上调肿瘤细胞表面 PD-L1 表达水平；以 MC38 肿瘤鼠为模型， 18.5 MBq 或 37 MBq 99m Tc-RGD 联合α PD-L1 抗体在间隔 4 h 时间窗 …
结果 经99mTc⁃RGD诱导后，CT26、MC38、4T1和B16F10肿瘤细胞表面的 PD⁃L1表达水平均显著上调，差异具有显著统计学意义（P均＜0 01）；以MC38肿瘤鼠为模型，对其注射 99m …
Integrin αvβ3-targeted radionuclide therapy combined with …
Healthy MC38 tumor-bearing female C57BL/6 mice were intravenously injected with 17-18 MBq of either 177 Lu-EB-RGD (n = 4) or 177 Lu-RGD (n = 4). Whole body SPECT images were …
Peptidic heterodimer-based radiotracer targeting fibroblast …
2024年1月26日 · In our pursuit of enhancing tumor uptake and retention, we designed and developed a novel peptidic heterodimer that synergistically targets both FAP and integrin α v β …
Glycoengineering-based anti-PD-1-iRGD peptide conjugate boosts ...
2024年6月18日 · Internalizing RGD (iRGD, c(CRGDKGPDC)), a promising tool in targeted drug delivery, operates through binding to αv integrins on tumor vasculature, facilitating …
【协和医学杂志】放射性药物联合免疫检查点抑制剂协同抗肿瘤研 …
在此基础上，本研究团队进一步探索了177Lu-DOTA-EB-cRGDfK（177Lu-DER）联合治疗的给药策略，在体内外证明了放射性核素刺激后PD-L1表达呈时间及剂量依赖性上调，在TRT后4 h通 …
RGD Peptide Cell-Surface Display Enhances the Targeting and …
In this study, we used a novel, easy and straightforward approach to generate engineered Salmonella ΔppGpp strains displaying the arginine-glycine-aspartate (RGD) peptide on the …
Active recruitment of anti–PD-1–conjugated platelets ... - Science
2023年3月29日 · Truncated tissue factor–Arg-Gly-Asp (RGD) (tTF-RGD), administered either by intravenous (i.v.) or p.t. routes, targets tumor neovasculature endothelial cells and initiates …
MC-38 Cell Line - Kerafast
MC-38 Cell Line derived from C57BL6 murine colon adenocarcinoma cells. From the laboratories of James W. Hodge, PhD, MBA and Jeffrey Schlom, PhD, National Cancer Institute/NIH. This …
靶向纳米药物破坏肿瘤细胞外基质屏障以提高药物输送和癌症治疗 …
2023年4月12日 · 与不含 HAase 的非靶向 IONP 相比，c (RGDyK)-HAase-IONP 在 MC38 荷瘤小鼠模型中静脉注射后显示出更好的肿瘤靶向效果（高 2.5 倍），这是通过全身荧光成像确定的 …